jararacussu and inferred that the venom produces an early edema onset dependent on prostanoid
production and neutrophil migration.
The management of such patients should comprise vasodilators including intravenous prostanoid
, treatment of concurrent sepsis, consideration of anti-platelet/anticoagulation, and where appropriate, surgical resection (3).
Cyclooxygenase-selective inhibition of prostanoid
formation: Transducing biochemical selectivity into clinical read-outs.
LDs are lipid inclusions implicated in prostanoid
2006; Richette and Bardin 2010).Its mechanism of action includes prostanoid
formation and alteration in chemokine function (Molad2002).
Non-steroidal anti-inflammatory drugs (NSAIDs) exert their anti-inflammatory and anti-tumor effects by reducing prostanoid
production via the inhibition of COX.
Kohan et al., "Thromboxane prostanoid
receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease," Hypertension, vol.
Side effects depend on the specific inhibition of prostanoid
synthesis due to the agent inducing the COX inhibition and the type of targeted tissue .
Flavahan, "Balancing prostanoid
activity in the human vascular system," Trends in Pharmacological Sciences, vol.
We next studied the expression level of enzymes involved in prostanoid
production in parasite-harboring hearts (Fig.
Serum lipoprotein, insulin, and urinary prostanoid
metabolites in normal and hypertensive pregnant women.
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