prostaglandin synthase

prostaglandin synthase

/pros·ta·glan·din syn·thase/ (sin´thās) an enzyme catalyzing the initial steps in the synthesis of prostaglandins from arachidonic acid; it comprises the component activities cyclooxygenase, catalyzing cyclization and oxidation reactions, and peroxidase, catalyzing a reduction reaction.
References in periodicals archive ?
1991) Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.
1995) Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
Under pharmacological blockade of prostaglandin synthase, ESEG-induced diuresis and electrolyte excretion were reduced to levels similar to those obtained with animals treated only with vehicle (Fig.
A significant increase in endothelial calcium stimulating eNOS and prostaglandin synthase occurs after activation of these receptors, which culminates with the release of several mediators, including NO, prostaglandins and tissue-type plasminogen activator.
2], which in turn is converted by terminal prostaglandin synthase enzymes to specific classes of prostaglandins.
Under the cooperation, Adeona will use Intrexon's advanced transgene engineering platform for the controlled, precise and continuous in vivo cellular production of prostaglandin synthase (PGIS), a specific effector enzyme that regulates prostacyclin production.
Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum.

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