alprostadil

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alprostadil

 [al-pros´tah-dil]
name for prostaglandin E1 when used pharmaceutically as a vasodilator and platelet aggregation inhibitor; used for treatment of patent ductus arteriosus and for diagnosis and treatment of impotence.

al·pros·ta·dil

(al-pros'tă-dil),
A vasodilator used for palliative therapy to maintain patency of the ductus arteriosus in neonates with congenital heart defects temporarily.
Synonym(s): prostaglandin E1

alprostadil

/al·pros·ta·dil/ (al-pros´tah-dil) name for prostaglandin E when used pharmaceutically as a vasodilator and platelet aggregation inhibitor; used for the treatment of patent ductus arteriosus and the diagnosis and treatment of impotence.

alprostadil

(ăl-prŏs′tə-dĭl)
n.
A prostaglandin drug, C20H34O5, that acts as a vasodilator and is used in suppository or injectable form to treat erectile dysfunction.

alprostadil

a proprietary form of prostaglandin E1 used to treat impotence and (temporarily) to maintain the patency of the ductus arteriosus in certain neonates.
indication It is recommended as palliative therapy for neonates awaiting surgery to correct congenital cardiac anomalies, such as tetralogy of Fallot and tricuspid atresia.
contraindications It is contraindicated in respiratory distress syndrome and in cases of known hypersensitivity. This drug is contraindicated in pregnant patients.
adverse effects The most common adverse effects are apnea, fever, seizures, cerebral bleeding, flushing, bradycardia, and hypertension.

alprostadil

Urology A formulation of PGE-1 which relaxes the corpus cavernosum, allowing engorging during erection. See Erectile dysfunction, Orgasm.

alprostadil

A PROSTAGLANDIN drug used by penile injection for the treatment of impotence. An erection lasting for two or three hours is commonly achieved, but sales of alprostadil may be adversely affected by the development of drugs such as VIAGRA. Brand names are Caverject, Muse, and Viridal Duo.

Alprostadil

A smooth muscle relaxant sometimes injected into the penis or applied to the urethral opening to treat impotence.
Mentioned in: Impotence

al·pros·ta·dil

(al-pros'tă-dil)
A vasodilator used for palliative therapy to maintain patency of the ductus arteriosus in neonates with congenital heart defects temporarily.
Synonym(s): prostaglandin E1.

alprostadil (alpros´tədil´),

n brand name: Caverject;
drug class: naturally occurring prostaglandin;
action: induces erection by relaxation of trabecular smooth muscle and by dilation of cavernosal arteries;
uses: treatment of erectile dysfunction caused by neurogenic, vasculogenic, psychogenetic, or mixed etiology.
References in periodicals archive ?
Prostaglandin E1 protects against ischemia-reperfusion injury of the liver by inhibition of neutrophil adherence to endothelial cells.
Misoprostol which is prostaglandin E1 analogue which was initially introduced for treatment of gastric ulcer in patients taking NSAID's because of its prostaglandin it is also very useful for cervical ripening and induction of labour.
Recent reports have determined that the reperfusion injury is improved by administration of verapamil, [sup][2] nicorandil, [sup][3],[4],[5] adenosine, [sup][6],[7] nitroprusside, [sup][8] anisodamine, [sup][9] or prostaglandin E1 (PGE1) [sup][10],[11] .
Misoprostol, a prostaglandin E1 analogue was used in obstetrics because of its uterotonic and cervical ripening effects in different studies (7, 10).
Effectiveness of intraportal prostaglandin E1 after liver transplantation Transplant Proc.
Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts.
Administration of synthetic prostaglandin E1 (Misoprostol) when metabolized acts systemically to stimulate mucous production.
The compound is an oral prostaglandin E1 analogue and was discovered from the companies' collaborative research, they said
Clinical application of prostaglandin E1 (PGEI) upon orthodontic tooth movement.
Other accepted options for treating ED include intracavernosal injection of vasoactive substances such as phentolamine or prostaglandin E1, or intraurethral insertion of prostaglandins.
If these drugs fail to work, older treatments such as vacuum constriction devices and injections of a substance known as prostaglandin E1 directly into the penis may be used to produce erections.