prostacyclin


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prostacyclin

 [pros″tah-si´klin]
a prostaglandin, PGI2, synthesized by endothelial cells lining the walls of arteries and veins; it is a potent vasodilator and a potent inhibitor of platelet aggregation. When used pharmaceutically it is called epoprostenol.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pros·ta·cy·clin

(pros'tă-sī'klin),
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.
Farlex Partner Medical Dictionary © Farlex 2012

prostacyclin

(prŏs′tə-sī′klĭn)
n.
A prostaglandin produced in the walls of blood vessels that acts as a vasodilator and inhibits platelet aggregation.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

prostacyclin

A short-acting hormone produced by the lining of blood vessels (ENDOTHELIUM) and by the lungs, that limits the aggregation of PLATELETS and is probably of major importance in preventing THROMBOSIS. Prostacyclin has a half-life of only 2–3 minutes.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
(1989) On the mechan ism of prostacyclin and thromboxane [A.sub.2] biosynthesis.
Dogne, "New developments on thromboxane and prostacyclin modulators part II: prostacyclin modulators," Current Medicinal Chemistry, vol.
Tanabe, Over expression of prostacyclin synthase inhibits growth of vascular smooth muscle cells, Biochemical and Biophysical Research Communication, 216(3), 862-867 (1995).
Estrogen a receptors are mainly present on vessels endothelial cells therefore when there are less a receptors there may be less NO and prostacyclin produced that may increase risks of thromboembolism in premenopausal women.
(15) Prostacyclin, a prostanoid, synthesized by COX-2 in the vascular endothelium, inhibits platelet aggregation and is responsible for the maintenance of homeostasis.
Infusion of prostacyclin following experimental brain injury in the rat reduces cortical lesion volume.
The constitutive enzyme cyclooxygenase 1 produces thromboxane [A.sub.2] in platelets and primarily prostacyclin in endothelial cells.
Nitric oxide (NO), prostaglandin (PG) [I.sub.2], that is, prostacyclin ([PGI.sub.2]), and thromboxane [A.sub.2] (Tx[A.sub.2]) are important short-lived signaling molecules involved in many physiological and pathological processes.
Irwin Mitchell said he was later diagnosed with a heart defect and wrongly given the drug Prostacyclin, which decreases blood flow to the vital organs, instead of Prostaglandin, which helps to keep the heart duct open.
However, critically ill patients with decompensated RV failure may not tolerate intravenous prostacyclin due to systemic hypotension or to shunting (1).
The three most important vasoactive endothelial-derived substances are nitric oxide (NO), endothelin, and prostacyclin. NO and prostacyclin act as vasodilators, whereas endothelin serves as a vasoconstrictor.