prostacyclin


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prostacyclin

 [pros″tah-si´klin]
a prostaglandin, PGI2, synthesized by endothelial cells lining the walls of arteries and veins; it is a potent vasodilator and a potent inhibitor of platelet aggregation. When used pharmaceutically it is called epoprostenol.

pros·ta·cy·clin

(pros'tă-sī'klin),
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

(prŏs′tə-sī′klĭn)
n.
A prostaglandin produced in the walls of blood vessels that acts as a vasodilator and inhibits platelet aggregation.

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

A short-acting hormone produced by the lining of blood vessels (ENDOTHELIUM) and by the lungs, that limits the aggregation of PLATELETS and is probably of major importance in preventing THROMBOSIS. Prostacyclin has a half-life of only 2–3 minutes.

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.
References in periodicals archive ?
(1989) On the mechan ism of prostacyclin and thromboxane [A.sub.2] biosynthesis.
Dogne, "New developments on thromboxane and prostacyclin modulators part II: prostacyclin modulators," Current Medicinal Chemistry, vol.
Tanabe, Over expression of prostacyclin synthase inhibits growth of vascular smooth muscle cells, Biochemical and Biophysical Research Communication, 216(3), 862-867 (1995).
Estrogen a receptors are mainly present on vessels endothelial cells therefore when there are less a receptors there may be less NO and prostacyclin produced that may increase risks of thromboembolism in premenopausal women.
These include the significance of the balance between prostacyclin and thromboxane [A.sub.2] for vascular homeostasis, the potential use of aspirin and related compounds in the prevention of cancer, endothelial dysfunction and the use of prostacyclin as a drug for the management of pulmonary hypertension.
(15) Prostacyclin, a prostanoid, synthesized by COX-2 in the vascular endothelium, inhibits platelet aggregation and is responsible for the maintenance of homeostasis.
Infusion of prostacyclin following experimental brain injury in the rat reduces cortical lesion volume.
The constitutive enzyme cyclooxygenase 1 produces thromboxane [A.sub.2] in platelets and primarily prostacyclin in endothelial cells.
Nitric oxide (NO), prostaglandin (PG) [I.sub.2], that is, prostacyclin ([PGI.sub.2]), and thromboxane [A.sub.2] (Tx[A.sub.2]) are important short-lived signaling molecules involved in many physiological and pathological processes.
Irwin Mitchell said he was later diagnosed with a heart defect and wrongly given the drug Prostacyclin, which decreases blood flow to the vital organs, instead of Prostaglandin, which helps to keep the heart duct open.
However, critically ill patients with decompensated RV failure may not tolerate intravenous prostacyclin due to systemic hypotension or to shunting (1).
The three most important vasoactive endothelial-derived substances are nitric oxide (NO), endothelin, and prostacyclin. NO and prostacyclin act as vasodilators, whereas endothelin serves as a vasoconstrictor.