proscillaridin


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pro·scil·lar·i·din

(prō'si-lar'i-din),
A cardiotonic agent prepared from squill, the sea onion Urginea maritima.
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The investigators reported that they have already identified one compound that was previously not known to affect KRAS, called Proscillaridin A.
Cardiac glycosides such as ouabain and proscillaridin were among the most potent compounds in the screen.
CMap name Enrichment P 8-Azaguanine 0.932 0.00004 Apigenin 0.86 0.00052 Chrysin 0.931 0.00056 Sulfametoxydiazine 0.855 0.00056 Lycorine 0.803 0.00068 Digoxin 0.846 0.0008 Prochlorperazine 0.467 0.00086 Sanguinarine 0.977 0.00087 Helveticoside 0.733 0.00097 Felbinac -0.847 0.00101 Adiphenine -0.771 0.00118 Diloxanide -0.83 0.00157 Etiocholanolone -0.704 0.00157 Heptaminol -0.753 0.0017 Acetylsalicylic acid 0.499 0.00174 Proscillaridin 0.903 0.00182 Cinchonine -0.82 0.00197 0316684-0000 -0.813 0.00229 Proadifen 0.806 0.00265 DL-Thiorphan 0.956 0.00342
Bovine adrenals and hypothalamus are a major source of proscillaridin A- and ouabain-immunoreactivities.