Benzedrex is a highly effective nasal decongestant inhaler formulated with propylhexedrine
, used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.
Tissue injuries associated with parenteral propylhexedrine
is a cycloalkylamine structurally similar to methamphetamine, the primary difference being the salicylic cyclohexyl group is present in lieu of an amphetamine's aromatic phenyl group (Wesson 1986).
Besides the Decision challenged, the Commission also adopted two further Decisions on March 9, 2000 concerning the withdrawal of marketing authorisations for medicinal products for human use containing: clobenzorex, fenbutrazate, fenproporex, mazindol, mefenorex, norpseudoephedrine, phenmetrazine, phendimetrazine and propylhexedrine
The analytical procedure was tested for interference with the following phenylpropylamine derivatives and common sympathomimetic amines: amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, ephedrine, pseudoephedrine, N-methylephedrine, amphetaminil, etilefrin, fencamfamine, fenethylline, fenfluramine, fenproporex, mefenorex, norfenefrine, phenylephrine, methylphenidate, diethylpropion, propylhexedrine
, and prolintane.
The company says that the product is specially formulated with propylhexedrine
, lavender oil and menthol, and promotes nasal and sinus drainage.
Other anorectics exist - fenbutrazate, mazindol, phenmetrazine and propylhexedrine
- but there are currently no authorisations to market medicines containing them in the European Union.The Commission said on March 27, when it announced the withdrawals, that it had taken so long to act on the advice of the CPMP because of the technical complexity of the process.