prophylactic oophorectomy

prophylactic oophorectomy

Oncology The excision of the ovaries in a ♀ with a mutation in BRCA1 or BRCA2–associated with a 5–60% lifetime risk of ovarian CA–normal risk is 1.5%–undergoes prophylactic removal of ovaries. See Bilateral mastectomy, Prophylactic mastectomy.
References in periodicals archive ?
Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations.
Additionally, we conducted falsification tests, examining trends in the number of reduction mammoplasty and bilateral prophylactic oophorectomy procedures within the same time frame using a similar approach.
BRCA1 carriers who undergo prophylactic oophorectomy may be reluctant to use HT for surgical menopause symptoms due to concerns it might increase their risk of breast cancer
Steven Narod stated in an ASCO News Release: "These data are so striking that we believe prophylactic oophorectomy by 35 should be the universal standard for women with BRCA1 mutations" because "waiting to have an oophorectomy until after 35 is too much of a chance to take." (363) This aggressive push to remove the ovaries and fallopian tubes from high risk women focuses narrowly on the decrease in risk in breast and ovarian cancer without acknowledging the increase in other risks following the procedure.
Oscarson, "Prophylactic oophorectomy in colorectal carcinoma," The American Journal of Surgery, vol.
Occult carcinoma in prophylactic oophorectomy specimens: prevalence and association with BRCA germline mutation status.
Elkadry suggested that there may be an accelerated trend toward prophylactic oophorectomy.
Options for women to consider include "intensive surveillance for breast cancer primarily, consideration of medications to reduce the risk of breast cancer, and either prophylactic mastectomy or prophylactic oophorectomy. If someone is BRCA positive, the role of the primary care clinician is to have an initial discussion of what the person would like to consider.