A comparison group included 124 patients who underwent prophylactic oophorectomy
with or without hysterectomy.
in carriers of BRCA1 or BRCA2 mutations.
Additionally, we conducted falsification tests, examining trends in the number of reduction mammoplasty and bilateral prophylactic oophorectomy
procedures within the same time frame using a similar approach.
BRCA1 carriers who undergo prophylactic oophorectomy
may be reluctant to use HT for surgical menopause symptoms due to concerns it might increase their risk of breast cancer
Steven Narod stated in an ASCO News Release: "These data are so striking that we believe prophylactic oophorectomy
by 35 should be the universal standard for women with BRCA1 mutations" because "waiting to have an oophorectomy until after 35 is too much of a chance to take." (363) This aggressive push to remove the ovaries and fallopian tubes from high risk women focuses narrowly on the decrease in risk in breast and ovarian cancer without acknowledging the increase in other risks following the procedure.
Oscarson, "Prophylactic oophorectomy
in colorectal carcinoma," The American Journal of Surgery, vol.
Occult carcinoma in prophylactic oophorectomy
specimens: prevalence and association with BRCA germline mutation status.
: a historical perspective.
Elkadry suggested that there may be an accelerated trend toward prophylactic oophorectomy
Options for women to consider include "intensive surveillance for breast cancer primarily, consideration of medications to reduce the risk of breast cancer, and either prophylactic mastectomy or prophylactic oophorectomy
. If someone is BRCA positive, the role of the primary care clinician is to have an initial discussion of what the person would like to consider.
Hormone replacement therapy and life expectancy after prophylactic oophorectomy
in women with BRCA1/2 mutations: a decision analysis.
is suggested after the hysterectomy because the risk of the ovarian cancer in long term (12).