prophage


Also found in: Dictionary, Encyclopedia, Wikipedia.

prophage

 [pro´fāj]
the latent stage of a bacteriophage in a lysogenic bacterium, in which the viral genome becomes inserted into a specific portion of the host chromosome and is duplicated into each cell generation.

pro·bac·te·ri·o·phage

(prō'bak-tē'rē-ō-fāj'),
The stage of a temperate bacteriophage in which the genome is incorporated in the genetic apparatus of the bacterial host.
Synonym(s): prophage

prophage

(prō′fāj′)
n.
The latent form of a bacteriophage in which the viral genes are incorporated into the bacterial chromosomes without causing disruption of the bacterial cell.

pro·bac·te·ri·o·phage

(prō'bak-tēr'ē-ō-fāj)
The stage of a temperate bacteriophage in which the genome is incorporated into the genetic apparatus of the bacterial host.
Synonym(s): prophage.

prophage

the DNA of a BACTERIOPHAGE that is repressed (see GENE REPRESSION) for LYTIC functions and that is maintained in the host bacterium in a stable state. The prophage may be integrated into the DNA of its bacterial host and may be replicated along with the host DNA, as is the case for BACTERIOPHAGE LAMBDA, or may be maintained as EXTRACHROMOSOMAL DNA, as is the case for bacteriophage P1. Prophage DNA may be carried between GENERATIONS (2) in this state and no phage particles are produced. However, the prophage normally retains the ability to direct a lytic cycle, by the activation of genes for lytic development. Upon INDUCTION (3), progeny phages are produced and released from the host. see LYSOGENY.
References in periodicals archive ?
These prophages have the ability to insert themselves into the chromosomal DNA of E.
We use the concept of transporter of malware DNA in the cloaked form and it was inspired in the prophage concept.
Highly variable phage (with the exception of annotated prophage regions), mobile elements, and intergenic regions were excluded from this portion of the analysis.
The genome possesses 8 to 10 prophages and nonfunctional phage remnants.
To promote their own survival within bacteria, phages have acquired additional genes not necessary for their lifecycle but provide a selective advantage for the host bacterium when the phage has integrated into the bacterial genome and is now a prophage. These fitness genes are known as "morons" and make the bacterium more competitive in the intestinal environment.
Brinkacet al., "Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements," BMC Microbiology, vol.
They are contained in a large prophage and have confirmed the characterization of isolates in wild ungulates [5].
report that the IS605 element family has homology at the protein level with orfB (putative transposase gene) [28]; this gene is present in a Salmonella prophage and contributes to virulence during bacterial infection [29].
Unexpectedly, the major differences in gene content and allele diversity were contributed by exogenous, mobile genetic elements, such as prophage. (38,39) Thus, these genomics data demonstrated that many of the long-recognized differences in strain virulence, disease phenotype, and epidemic behavior of GAS strains from different serotypes are likely due to genes encoded on prophage, rather than on the core chromosome.
In addition, the fur mutation displayed an increased synthesis of PBSX defective prophage encoded proteins.
-- Phase 2: Prophage Series G-100 for newly diagnosed glioma -- Phase 2: Prophage Series G-200 for recurrent glioma -- Phase 2 Ready: HerpV (contains QS-21 Stimulon) for genital herpes