properdin


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properdin

 [pro´per-din]
a protein of the alternative complement pathway, augmenting complement activation. Called also factor P.

pro·per·din

(prō'per-din),
A control protein for the alternate complement cascade, properdin stabilizes the C3 convertase enzyme, a deficiency of which increases susceptibility to systemic meningococcal infections and can be inherited in an x-linked pattern.
See also: properdin system, component of complement, factor P.
[pro- + L. perdo, to destroy]

properdin

/pro·per·din/ (pro´per-din) factor P; a nonimmunoglobulin gamma globulin component of the alternative pathway of complement activation.

properdin

(prō-pûr′dn)
n.
A protein in blood serum that is a component of the innate immune system, acting as a positive regulator of the alternative pathway of the complement system.

pro·per·din

(prō'pĕr-din)
A group of proteins involved in resistance to infection that participate, in conjunction with other factors, in an alternate pathway to the activation of the terminal components of complement.
See also: properdin system, component of complement
[pro- + L. perdo, to destroy]

properdin

a normal, relatively heat-labile, nonantibody serum protein (a euglobulin) that, in the presence of complement component C3 and magnesium ions, is involved in the alternative complement pathway, and acts nonspecifically against gram-negative bacteria and viruses and plays a role in lysis of erythrocytes. It may act in conjunction with complement-fixing antibody.

properdin pathway
alternative complement pathway.
References in periodicals archive ?
Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease," Journal of Biological Chemistry, vol.
Association between combined properdin and mannose-binding lectin deficiency and infection with Neisseria meningitidis.
Gliatech is developing therapeutic antibodies to properdin as potential treatments for acute inflammatory conditions which result from cardiopulmonary bypass surgery, heart attacks and stroke.
Acquiring rights from Gliatech to antibodies against the complement protein properdin.
C3, properdin, Factor D, Factor H, or C5-C9); persons receiving eculizumab (Soliris, Alexion Pharmaceuticals) for treatment of atypical hemolytic uremic syndrome or paroxysmal nocturnal hemoglobinuria (because the drug binds C5 and inhibits the terminal complement pathway); and persons with functional or anatomic asplenia (including persons with sickle cell disease).
The malarial sporozoites once injected in blood by the bite of female Anopheles mosquitoes are attached to hepatocytes through receptor for thrombospondin and properdin.
Children who have persistent complement component deficiencies (eg, C5-C9, properdin, factor H, or factor D); those traveling to (or residents of) countries where meningococcal disease is hyperendemic or epidemic; or those who are in a defined risk group during a community or institutional meningococcal outbreak.
Terminal kompleman sistem [C3 eksikligi, C5-C9] eksikligi, properdin eksikligi, anatomik veya fonksiyonel aspleni olan kisiler invaziv meningokok hastaligi gorulme riski yuksek gruplardir.
Beachwood, OH; 216-831-3200) under which Gliatech will use Abgenix' XenoMouse technology to generate fully human monoclonal antibodies to the complement protein properdin for use in the fields of cardiovascular and inflammatory diseases.
Nasdaq:GLIA) today announced an agreement that provides Abgenix with exclusive worldwide rights to human monoclonal antibody therapies against the complement protein properdin as potential treatments for cardiovascular and inflammatory diseases.
C3, properdin, Factor D, Factor H, or C5-C9) have up to a 10,000-fold increased risk for meningococcal disease and can experience recurrent disease (16,17).