propentofylline


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propentofylline

Neurology An agent that may help improve mental performance in dementia. See Dementia.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
For example, IL-1[beta] treatment caused wind-up in spinal dorsal horn sensory neurons; moreover, this effect was attenuated by propentofylline (PPF), a glial modulator that inhibits astrocytic and microglial activation [136].
Moreover, intrathecal addition of the glial inhibitor propentofylline reduced thermal hyperalgesia and mechanical allodynia in CCI rats and also reduced MAPK activation in CCI rats and in naive rats treated with a VPAC2 agonist, suggesting involvement of glial cells in nerve injury-induced sensitization [144].
DeLeo, "Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats," Neuropsychopharmacology, vol.
Cabral et al., "Propentofylline prevents sickness behavior and depressive-like behavior induced by lipopolysaccharide in rats via neuroinflammatory pathway," PLoS ONE, vol.
No drugs have been approved to specifically treat feline CD, but veterinarians can prescribe some medications, such as selegiline and propentofylline, "off-label," as well as therapeutic diets intended to improve cognitive function.
De Leo, "Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia," Neuro-Oncology, vol.
Propentofylline in the treatment of vascular dementia and Alzheimer-type dementia: overview of phase I and phase II clinical trials.
The effects of local pentoxifylline and propentofylline treatment on formalin-induced pain and tumor necrosis factor-alpha messenger RNA levels in the inflamed tissue of the rat paw.
Propentofylline increases the oxygenation of tissue, especially the brain, heart and muscle.
Patients with Alzheimer's disease and vascular dementia responded well to propentofylline, a drug that may become available in the United States within the next few years.
Propentofylline in adult onset cognitive disorders: double-blind, placebo controlled, clinical, psychometric and brain mapping studies.
Although human studies have established glial activation in chronic pain states using functional magnetic resonance imaging [70] and in postmortem spinal cords [71], clinical trial with inhibitors targeting microglia, such as minocycline (a tetracycline antibiotic) and propentofylline (a CNS glial modulator), has shown no or limited promise in chronic pain [15].