propafenone


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propafenone

 [pro″pah-fe´nōn]
a sodium channel blocking agent that acts on the Purkinje fibers and the myocardium; used as the hydrochloride salt in treatment of life-threatening arrhythmias, administered orally.

propafenone

/pro·pa·fe·none/ (pro″pah-fe´nōn) a sodium channel blocking agent acting on the Purkinje fibers and the myocardium; used as the hydrochloride salt as an antiarrhythmic.

propafenone

Rythmol® Cardiology A beta-blocking antiarrhythmic for severe ventricular and supraventricular arrhythmias–A Fib, V Tach, conduction block, HTN Complications Ventricular proarrhythmia; conduction defects Adverse effects Neurologic–headache, dizziness, paresthesias, peripheral neuropathy, GI–eg, N&V, anorexia. See Antiarrhythmic, Beta-blockers.

propafenone

A drug used to treat heart irregularities (arrhythmias). A brand name is Arythmol.

propafenone (prō´pəfē´nōn),

n brand name: Rythmol;
drug class: antidysrhythmic (Class IC);
action: able to slow conduction velocity; reduces cardiac muscle membrane responsiveness; inhibits automaticity; increases ratio of effective refractory period to action potential duration; β-blocking activity;
use: documented life-threatening dysrhythmias.
References in periodicals archive ?
Rhythm control medications, including flecainide (Tambocor), propafenone (Rythmol), Sotalol (Betapace), amiodarone (Cordarone, Pacerone), and dronedarone (Multaq)
Patients randomized to the antiarrhythmic drug arm of the study received treatment with one of six eligible drugs: amiodarone, disopyramide, dronedarone, flecainide, propafenone, or sotalol.
received final approval for propafenone hydrochloride extended-release capsules USP, 225 mg, 325 mg and 425 mg, the generic version of GlaxoSmithKline PLC's Rythmol SR.
The US Food and Drug Administration (FDA) granted its approval for Propafenone Hydrochloride extended-release capsules USP, 225 mg, 325 mg and 425 mg.
It also launched Propafenone Hydrochloride extended-release capsules, the generic of GlaxoSmithKline's Rythmol capsules.
Patients were divided into three groups: group A included patients with no POAF prophylaxis; group B included patients with diltiazem prophylaxis; and group C included patients with preoperative antiarrhythmic therapy (mostly beta-blockers, a few propafenone or amiodarone) that was continued postoperatively.
44) Patients with paroxysmal AF may be candidates for a "pill-in-the-pocket" strategy using propafenone or flecainide.
Coparison of effects of liposomal amphotericin B and conventional propafenone metabolism and hepatic cytochrome P-450 in rats.
After 12 hours fasting propafenone infusion was started intravenously, and electrical CV was performed under anesthesia in the coronary intensive care unit.
lmplementation of QbD approach to the analytical method development and validation for the estimation of propafenone hydrochloride in tablet dosage form.
Efficacy of substituting innovator propafenone for its generic formulation in patients with atrial fibrillation.