Depending on the conditions and concentration, antioxidants may exhibit a prooxidant
activity is exacerbated by extreme conditions such as capture, which induces a wide range of physiological alterations related to physical overexertion, including hypoxia and hemorrhage (Gelsleichter, 2004).
The predominance of reducing ability over the free radical scavenging activity results in the prooxidant
effect (Lahbib et al.
studied the oxo-degradability of expanded atactic polystyrene (PS) that are formulated with cobalt and manganese based prooxidant
Both the quality and acceptability of meat products is mainly determined by lipid and protein oxidation , Salted, fermented sausages are especially susceptible to oxidation since salt has been proven to be a prooxidant
in meat products.
although at the same time it is the source of oxidizable substrates like polyunsaturated fatty acids and prooxidant
metals (iron, copper, etc.
Cadmium is a non-redox metal and unable to participate in Fenton-type reactions but causes oxidative stress via overproduction of reactive oxygen species (ROS), disturbing the equilibrium between prooxidant
and antioxidant homeostasis (Garnier et al.
10) Additionally Drisko's work has concluded that it is the prooxidant
effect of high-dose intravenous ascorbic acid that confers the cancer-controlling effect, not the antioxidant effect of oral low-dose ascorbic acid.
GSH depletion has previously been observed after exposure to BPA and has been hypothesized to contribute to its prooxidant
effects (Babu et al.
Oxidative stress is thought to be enhanced in patients on hemodialysis due to the presence of fewer natural anti-oxidants and increased prooxidant
stimuli, including diabetes, uremia, advanced age, inflammation, and potential responses to dialyzers (Locatelli et al.
This biphasic mode of antioxidant and prooxidant
activities of EGCG has also been observed in other models [52, 53].
The presence of toxin with prooxidant
properties, malnutrition, systemic inflammation, weakened antioxidant defense system, drugs, and side effects of dialysis contribute to the disruption of redox homeostasis and development of oxidative stress in patients with CKD .