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pro·o·pi·o·mel·a·no·cor·tin (POMC),(prō-ō'pē-ō-mel'ă-nō-kōr'tin), [MIM*176830]
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta; the precursor of ACTH, CLIP, β-LPH, γ-MSH, β-endorphin, and met-enkephalin.
Farlex Partner Medical Dictionary © Farlex 2012
POMCA gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
proopiomelanocortin (POMC)The prohormone from which ACTH, beta-lipotropin, and beta-ENDORPHIN are produced by cleavage. POMC is found most abundantly in the pituitary and hypothalamus, but also occurs in the sex glands and elsewhere.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005