promyelocyte

[pro-mi´ĕ-lo-sīt″]

a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few undifferentiated cytoplasmic granules.

pro·my·e·lo·cyte

(prō-mī'ĕ-lō-sīt'),

1. The developmental stage of a granular leukocyte between the myeloblast and myelocyte, when a few specific granules appear in addition to azurophilic ones.

2. A large uninuclear cell occurring in the circulating blood of persons with myelocytic leukemia.

Synonym(s): premyelocyte, progranulocyte

[pro- + G. myelos, marrow, + kytos, cell]

Farlex Partner Medical Dictionary © Farlex 2012

promyelocyte

(prō-mī′ə-lə-sīt′)

A cell containing a few granules that develops from a myeloblast and develops into a myelocyte during the differentiation of a granulocyte.

pro·my·e·lo·cyte

(prō-mī'ĕ-lō-sīt)

1. The developmental stage of a granular leukocyte between the myeloblast and myelocyte, when a few specific granules appear in addition to azurophilic ones.

2. A large mononuclear cell of bone marrow representing an undifferentiated stage in the development of a granulocyte, between myeloblast and myelocyte; contains only a few undifferentiated cytoplasmic granules; rare in circulating blood except in myelocytic leukemias.
Synonym(s): premyelocyte, progranulocyte.

[pro- + G. myelos, marrow, + kytos, cell]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

promyelocyte

(pro-mi'el-o-sit) [Gr. pro, before, + myelos, marrow, + kytos, cell]

1. A large mononuclear myeloid cell seen in the blood in leukemia.

PROMYELOCYTE

2. Cell development between a myeloblast and a myelocyte, resembling a myeloblast. Synonym: progranulocyte See: illustration

References in periodicals archive ?

Promyelocyte, myelocyte, metamyelocyte, band and mature neutrophil forms were absent.

Neutropenic Fever in a Two-and-a-Half Month Old Girl: Severe Congenital Neutropenia

Myelograms of animals from G2 showed a significant decrease in the total number of rubriblasts and promyelocytes when compared to animals from G1 (P<0.05).

Aqueous wheat extract (Triticuma estivum) prevents carboplatin-induced myelosuppression and oxidative stress in Wistar rats/Extrato aquoso de trigo (Triticum aestivum) na prevencao da mielossupressao e estresse oxidativo induzidos pela carboplatina em ratos Wistar

All-transretinoic acid (ATRA), a vitamin A derivative, binds to the RARA site of the PML-RARA fusion protein in APL cells and allows the leukemic promyelocytes to differentiate into mature granulocytes.

Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate

Peripheral blood smear examination revealed conspicuous atypical lymphocytes and occasional promyelocytes (Figure 1A and 1B).

Acute promyelocytic leukemia and chronic lymphocytic leukemia: concomitant presentation of two molecularly distinct entities

The HL-60 human promyelocyte leukemia cell line was kindly supplied by the Japanese Cancer Research Resource Bank (Osaka, Japan).

Benzene metabolite 1,2,4-Benzenetriol induces halogenated DNA and tyrosines representing halogenative stress in the HL-60 human myeloid cell line

Tissue examination showed granulocytic cells in different stages of maturation, but with a distinct and prominent shift toward immature forms at the promyelocyte and myelocyte stages.

Intracerebral granulocytic sarcoma

phagocytophilum (strain USG3 propagated in HL60 promyelocyte cells), IgM and IgG antibodies to E.

Concomitant tickborne encephalitis and human granulocytic ehrlichiosis

Two important applications of FISH are seen in the diagnosis of patients with chronic myeloid leukemia (CML) and acute promyelocyte leukemia (APL).

FISHing in the genomic testing age

Studies have shown that FAMLF was highly expressed in acute myeloid leukemia and BL patients, NB4 acute promyelocyte leukemia cells, U937 macrophage-like cells, K562 myeloid leukemia cells, U266 myeloma cells, HL60 promyelocytic cells, CA46 lymphoma cells, and especially in Raji BL cells, while low expression was observed in unaffected individuals.

FAMLF is a target of miR-181b in Burkitt lymphoma

Neutrophil serine proteases are activated early in the promyelocyte stage of neutrophil development via cleavage of a dipeptide, by the cysteine protease dipeptidyl peptidase 1 (DPP1, also known as cathepsin C [100]).

Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease

The human liposarcoma cell line (SW872), the human synovial sarcoma cell line (SW982), the human bone osteosarcoma cell line (HS 39.T), the human connective tissue leiomyosarcoma cell line (HS 5.T), the human acute promyelocyte leukemia cell line (HL-60), the human melanoma cell line (M14WM), the human breast adenocarcinoma cell line (MCF-7), and the human colon carcinoma (HT29) cell lines were purchased from American Type Culture Collection (Rockville, MD).

In Vitro Screening for Cytotoxic Activity of Herbal Extracts

Agranulocytosis with arrested maturation at the promyelocyte stage may be confused for APL; however, in agranulocytosis the patient's platelet count and hemoglobin are typically normal, the bone marrow is not hypercellular, and Auer rods are not observed.