promyelocyte

[pro-mi´ĕ-lo-sīt″]

a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few undifferentiated cytoplasmic granules.

pro·my·e·lo·cyte

(prō-mī'ĕ-lō-sīt'),

1. The developmental stage of a granular leukocyte between the myeloblast and myelocyte, when a few specific granules appear in addition to azurophilic ones.

2. A large uninuclear cell occurring in the circulating blood of persons with myelocytic leukemia.

Synonym(s): premyelocyte, progranulocyte

[pro- + G. myelos, marrow, + kytos, cell]

promyelocyte

/pro·my·elo·cyte/ (-mi´il-o-sīt″) a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few, as yet undifferentiated, cytoplasmic granules.promyelocyt´ic

promyelocyte

(prō-mī′ə-lə-sīt′)

A cell containing a few granules that develops from a myeloblast and develops into a myelocyte during the differentiation of a granulocyte.

promyelocyte

[prōmī′ələsīt′]

precursor in the bone marrow myelocytic series that is intermediate in development between a myeloblast and a myelocyte. The cytoplasm contains prominent primary granules. Appears in peripheral blood in acute promyelocytic leukemia.

Promyelocyte

pro·my·e·lo·cyte

(prō-mī'ĕ-lō-sīt)

1. The developmental stage of a granular leukocyte between the myeloblast and myelocyte, when a few specific granules appear in addition to azurophilic ones.

2. A large mononuclear cell of bone marrow representing an undifferentiated stage in the development of a granulocyte, between myeloblast and myelocyte; contains only a few undifferentiated cytoplasmic granules; rare in circulating blood except in myelocytic leukemias.
Synonym(s): premyelocyte, progranulocyte.

[pro- + G. myelos, marrow, + kytos, cell]

promyelocyte

(pro-mi'el-o-sit) [Gr. pro, before, + myelos, marrow, + kytos, cell]

1. A large mononuclear myeloid cell seen in the blood in leukemia.

PROMYELOCYTE

2. Cell development between a myeloblast and a myelocyte, resembling a myeloblast. Synonym: progranulocyte See: illustration

promyelocyte

a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few, as yet undifferentiated, cytoplasmic granules.

References in periodicals archive ?

Peripheral blood smear examination revealed conspicuous atypical lymphocytes and occasional promyelocytes (Figure 1A and 1B).

Acute promyelocytic leukemia and chronic lymphocytic leukemia: concomitant presentation of two molecularly distinct entities

Both forms have promyelocytes with abnormal bilobed nuclei.

Acute Promyelocytic Leukemia: A Review and Discussion of Variant Translocations

Retinoic acid and arsenic for treating acute promyelocyte leukemia.

An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis

These toxic granules are formed in the promyelocyte stage during neutrophil maturation, and contain antimicrobial substances.

The correlation between C-reactive protein and toxic granulation of neutrophils in the peripheral blood

1; q22); CBFB-MYH11 Acute promyelocyte leukemia with AML with maturation t(15; 17)(q22; q12); PML-RARA AML with t(9; 11)(p22; q23); Acute myelomonocytic leukemia MLLT3-KMT2A(MLL) AML with t(6; 9)(p23; q34); Acute monoblastic and monocytic DEK-NUP214 leukemia AML with inv(3)(q21q26.

Acute Myeloid Leukemia Genetics: Risk Stratification and Implications for Therapy

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocyte leukemia.

Anti-tumor potential of ethanol extract of curcuma phaeocaulis valeton against breast cancer cells

Although there is a general consensus concerning the criterion for identifying myeloblasts as agranular (type I) and granular blasts (types II and III), there is some disagreement concerning their definitions, and in practice it may be a matter of convention (subjective method) to differentiate them from the continuum of cells, such as determining whether the cell is a type III blast or a promyelocyte.

"Arbitrary" criterion for the diagnosis of acute leukemia / Akut losemi tanisina yonelik "rastgele" kriter

Stimulation of interleukin-S production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline.

Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells

Antigen derived from human promyelocyte cell culture (HL-60) infected with the agent of HGE obtained from Westchester County, New York.

Disparity in the Natural Cycles of Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis

B, Bone marrow aspirate smear showing promyelocyte with bilobed nuclei, prominent nucleoli, and basophilic microgranular cytoplasm consistent with variant M3 morphology (case 3) (Wright-Giemsa, original magnifications X1000).

Immunostaining for rapid diagnosis of acute promyelocytic leukemia with the tetramethylrhodamine 5-isothiocyanate--conjugated anti-promyelocytic leukemia monoclonal antibody PG-M3

Antiproliferative activity of various Uncaria tomentosa preparations on HI-60 promyelocyte leukemia cells.

Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway

In this study we investigated the in vitro effects of resveratrol on the apoptotic cascades in human promyelocyte leukemia (HL-60) cells and first demonstrated that growth arrest- and DNA damage-induced gene 45 [alpha] (GADD45 [alpha]) and annexin A1 are involved in the apoptosis effects of resveratrol in these cells.

GADD45[alpha], and annexin A1 are involved in the apoptosis of HL-60 induced by resveratrol

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