By that time, it was proposed by van Furth and Cohn that, like any other tissue-resident macrophages, AM originated from bone marrow promonocyte
precursors, which then circulated in the blood as monocytes and could differentiate into macrophages within the alveoli .
Buffolo et al., "Long-term and sustained therapeutic results of a specific promonocyte
cell formulation in refractory angina: ReACT[R] (refractory angina cell therapy) clinical update and cost-effective analysis," Cell Transplantation, vol.
Kos, "Inhibitory properties of cystatin F and its localization in U937 promonocyte
cells," FEBS Journal, vol.
It has recently been reported that Japanese encephalitis virus (JEV) induces apoptosis in human promonocyte
cells through ASK1 activation.
In TLR4-stimulated THP-1 promonocytes
, SIRT1 accelerated the shift between glycolysis and fatty acid oxidation in the early stage of the inflammatory response, thus promoting the body into the late inflammation.
Peripheral blood smear demonstrated increased blasts with promonocytes
consistent with AML (Figure 1).
His blood film showed marked monocytosis, promonocytes
, and some circulating blasts suggesting acute myelomonocytic leukemia (AMML) or chronic myelomonocytic leukemia (CMML) in transformation.
Zheng et al., "Induction of functional human macrophages from bone marrow promonocytes
by M-CSF in humanized mice," The Journal of Immunology, vol.
Compared with mature monocyte in circulation, immature precursors such as monoblasts and promonocytes
, which could not be observed in the peripheral blood of healthy individuals, are larger and exhibit lower granularity [54, 55], which seemed in line with the features of A Mo in our study.
LC can be defined as myeloid sarcoma or granulocytic sarcoma, in which the infiltrate is characterized by neoplastic granulocytic precursors; otherwise, when the infiltrate is composed of neoplastic monocytic precursors (monoblasts and promonocytes
), LC can be labeled monoblastic sarcoma (1).
Peripheral smear showed many promonocytes
and a few immature blasts containing rare Auer rods consistent with a diagnosis of AML.
Effects of exogenous stress protein 70 on the functional properties of human promonocytes
through binding to cell surface and internalization.