promethazine


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promethazine

 [pro-meth´ah-zēn]
a phenothiazine derivative having marked antihistaminic activity as well as sedative and antiemetic actions; used to provide bedtime, surgical, and obstetrical sedation, to treat allergic conditions including rhinitis, conjunctivitis, and itching, to manage nausea, vomiting, and vertigo associated with surgery, pregnancy, or motion sickness, and as an ingredient in cough and cold preparations; administered orally, rectally, intramuscularly, and intravenously as the hydrochloride salt.

promethazine

An ANTIHISTAMINE drug used to relieve itching, to control motion sickness and as a sedative. The drug is on the WHO official list. A brand name is Phenergan.
References in periodicals archive ?
Specialist pharmaceutical company Mylan Inc (Nasdaq:MYL) reported on Friday the receipt of final approval from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Promethazine Hydrochloride (HCl) Tablets USP, 12.5 mg, 25 mg and 50 mg.
Promethazine HCl Tablets are used to relieve the symptoms of certain allergic reactions, such as perennial and seasonal allergic rhinitis, Mylan added.
* PHYSICIAN'S DEFENSE The physician's return to the ED was proper because he handed over care to the critical care physician; promethazine was not contraindicated; appropriate care was provided, including attempts at resuscitation.
Nonetheless, cases of severe tissue injury following IV administration of promethazine continue to be reported.
Physicians also are being urged to exercise caution when administering promethazine HCl medications to pediatric patients 2 years and older.
Added to the existing warning in the label was the statement, "Respiratory depression and apnea, sometimes associated with death, are strongly associated with promethazine products and are not directly related to individualized weight-based dosing, which might otherwise permit safe administration."
The Food and Drug Administration has issued a safety warning to alert health care professionals that promethazine HC1 in all forms, including syrup, is contraindicated in children younger than 2 years of age.
The list of potentially inappropriate drugs included: propoxyphene, indomethacin, pentazocine, methocarbamol, carisoprodol, oxybutynin, chlorzoxazone, metaxalone, cyclobenzaprine, flurazepam, amitriptyline, doxepin, meprobamate, lorazepam, oxazepam, alprazolam, temazepam, zolpidem, triazolain, chlordiazepoxide, diazepam, hydroxyzine, promethazine, all barbiturates (except phenobarbital), and meperidine.
Options include topical benzocaine or analgesia with acetaminophen, a non-steroidal anti-inflammatory agent, or codeine plus promethazine with or without additional acetaminophen.
Contract notice: conclusion of non-exclusive discount agreements pursuant to section 130a (8) sgb v on medicines containing the active substance promethazine (atc: n05cm22) as part of a so-called open-house model.
4 Phenergan Elixir, PS4.49 for 100ml, www.expresschemist.co.uk Contains promethazine, an antihistamine with gentle sedative properties.
"Our new product introductions such as promethazine plain, promethazine with codeine and promethazine with DM are important contributors to our customers' bottom lines," says Edwin Berrios, Hi-Tech's vice president of sales and marketing.