prolymphocyte


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prolymphocyte

 [pro-lim´fo-sīt]
a cell of the lymphocytic series intermediate between the lymphoblast and the lymphocyte.

prolymphocyte

/pro·lym·pho·cyte/ (pro-lim´fo-sīt) a developmental form in the lymphocytic series, intermediate between the lymphoblast and lymphocyte.

prolymphocyte

Hematology A large lymphocyte- 'wannabe' not normally found in the peripheral circulation which has a high–5:1 to 3:1–N:C ratio; the centrally placed, round, ovoid or slightly indented nucleus has minimal coarse chromatin clumps along the margin, indistinct parachromatin, a large, round bluish nucleolus; organelles are indistinct; cytoplasm is medium to deep homogeneous blue and greater in prolymphocytes than in lymphoblasts or mature lymphocytes. Cf Little blue cell, Lymphoblast.

prolymphocyte

a cell of the lymphocytic series intermediate between the lymphoblast and lymphocyte.
References in periodicals archive ?
After a course of treatment, the patient showed refractory pleural effusion, in which prolymphocyte was found.
His prolymphocyte count remained less than 5% and there was no evidence of large cell transformation.
B-cell prolymphocyte leukemia (B-PLL) is a somewhat ill-defined, uncommon entity characterized by marked peripheral lymphocytosis composed of more than 55% prolymphocytes (large lymphocytes with a prominent central nucleolus).
Bone marrow aspirate smear revealed lymphocyte dominance at the rate of 60% without increased prolymphocytes.
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive post-thymic malignancy that is characterized by the proliferation of small- to medium-sized prolymphocytes.
Nuclear staining with LEF1 is positive in lymphoma cells of SLL; the nuclear staining is stronger in prolymphocytes and in the transformed large lymphoma cells of Richter syndrome (not shown) (original magnification X500).
In the late 1990s, various groups reported a correlation between clinical outcome and Rai stage with respect to the morphology of CLL lymphocytes, the pattern ofbone marrowinfiltration, lymphocyte doubling time, and the percentage of prolymphocytes.
For CLL samples, the CBC report needs to include both the lymphocyte count and lymphocyte morphologic features, such as the presence of prolymphocytes, atypical lymphocytes, or smudge cells.
A diagnosis of full blown PLL is usually associated with more than 55% circulating prolymphocytes.
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm of small, round, mature B lymphocytes, often admixed with prolymphocytes and paraimmunoblasts.