prolymphocyte


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prolymphocyte

 [pro-lim´fo-sīt]
a cell of the lymphocytic series intermediate between the lymphoblast and the lymphocyte.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

prolymphocyte

Hematology A large lymphocyte- 'wannabe' not normally found in the peripheral circulation which has a high–5:1 to 3:1–N:C ratio; the centrally placed, round, ovoid or slightly indented nucleus has minimal coarse chromatin clumps along the margin, indistinct parachromatin, a large, round bluish nucleolus; organelles are indistinct; cytoplasm is medium to deep homogeneous blue and greater in prolymphocytes than in lymphoblasts or mature lymphocytes. Cf Little blue cell, Lymphoblast.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
One of our patients was seropositive for HIV and the other had T-cell prolymphocyte leukemia, which suggests that lymphopenia could be a key risk factor.
Vural, "Rituximab-induced acute thrombocytopenia in a patient with prolymphocyte leukemia," American Journal of Hematology, vol.
After a course of treatment, the patient showed refractory pleural effusion, in which prolymphocyte was found.
His prolymphocyte count remained less than 5% and there was no evidence of large cell transformation.
B-cell prolymphocyte leukemia (B-PLL) is a somewhat ill-defined, uncommon entity characterized by marked peripheral lymphocytosis composed of more than 55% prolymphocytes (large lymphocytes with a prominent central nucleolus).
B-cell prolymphocytic transformation is diagnosed in progressive organomegaly and lymphocytosis with increase of prolymphocytes >55% and is treated as aggressive CLL.
Bone marrow aspirate smear revealed lymphocyte dominance at the rate of 60% without increased prolymphocytes. The karyotype analysis revealed 46XY karyotype, and chromosome analysis revealed no chromosomal anomaly.
A May-Griinwald-Giemsa-stained peripheral blood film revealed typical small mature lymphocytes with condensed chromatin, with less than 10% of prolymphocytes. A typical CLL phenotype was found with 80% of B cells CD19+ with coexpression of CD5, CD23, CD200, and lambda light chain restriction and weak expression of CD20, CD22, and CD79b.
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive post-thymic malignancy that is characterized by the proliferation of small- to medium-sized prolymphocytes. (1) It has distinctive clinical, morphological, immunophenotypic, and cytogenetic features and accounts for less than 2% of all forms of small lymphocytic leukemias in adults over the age of 30.
Nuclear staining with LEF1 is positive in lymphoma cells of SLL; the nuclear staining is stronger in prolymphocytes and in the transformed large lymphoma cells of Richter syndrome (not shown) (original magnification X500).
In the late 1990s, various groups reported a correlation between clinical outcome and Rai stage with respect to the morphology of CLL lymphocytes, the pattern ofbone marrowinfiltration, lymphocyte doubling time, and the percentage of prolymphocytes.