prolyl hydroxylase


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pro·lyl hy·drox·y·lase

an enzyme that catalyzes the hydroxylation of certain prolyl residues in collagen precursors using molecular oxygen, ferrous ion, ascorbic acid, and α-ketoglutarate; a vitamin C deficiency directly affects the activity of this enzyme; one form of this enzyme (prolyl 4-hydroxylase) synthesizes 4-hydroxyprolyl residues while another produces 3-hydroxyprolyl residues.
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References in periodicals archive ?
The enzymes involved are prolyl hydroxylases and lysyl hydroxylase and the reactions require [O.
Berchner-Pfannschmidt, "Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia," Free Radical Research, vol.
Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)," Proceedings of the National Academy of Sciences of the United States of America, vol.
A Rieske-type [2Fe-2S] cluster serves as an electron-transferring cofactor, and a mononuclear iron site is the putative site for substrate oxygenation, similar to that predicted in prolyl hydroxylases [prolyl hydroxylase domain (PHD) enzymes] (Batie and Ballou 1990).
According to the companies, Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) that acts by stimulating the body's natural pathway of red blood cell production, or erythropoiesis.
The product is aimed at stabilising hypoxia inducible factor, a transcription factor that regulates the expression of genes involved with red blood cell production in response to changes in oxygen levels, by inhibiting the HIF prolyl hydroxylase (HIF-PH) enzyme.