Tolerase G--or Aspergillus niger prolyl
endoprotease (AN-PEP)--is positioned for the rising number of gluten sensitive consumers following a gluten-free diet who want help digesting hidden or residual gluten that may be found in a broad range of foods.
HIF-1 is a transcription factor and a heterodimer composed of two subunits: HIF-1a and HIF-1b (aryl hydrocarbon receptor nuclear translocator), whose pathway is targeted to control angiogenesis via the silencing of prolyl
hydroxylase domain-containing protein 2 (PHD2) [1, 18].
2] concentration caused the inhibition of Prolyl
hidroxylases (PHDs) enzyme expression which caused the formation of Hypoxia Inducible Factor-1 (HIF-1) complex.
alpha-Lipoic acid induces collagen biosynthesis involving prolyl
hydroxylase expression via activation of TGF-beta-Smad signaling in human dermal fibroblasts.
Roxadustat is the first compound in a potential new therapeutic class known as hypoxia-inducible factor (HIF) prolyl
hydroxylase inhibitors (or HIF-PHIs) to enter Phase III studies.
PhytoMemory inhibited prolyl
endopeptidase (PEP), which has been previously characterized as a promising therapeutic target for supporting learning, memory, and mood.
Because phosphorylation at proline-directed sites causes cis-isomerization of the protein backbone, we tested this effect on DAT T53 by inhibiting Pin1, a peptidyl prolyl
isomerase which catalyzes the isomerization of pThr/pSer backbones using a small molecule inhibitor, juglone.
Under low oxygen conditions, vitamin C acts as a cofactor to a prolyl
hydroxylase (PHD) that in turn hydroxylates hypoxia inducible factor (HIF)-2[alpha].
3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta.
Targeting carcinogenesis: a role for the prolyl
Laboratory studies with cells have shown that an enzyme known as prolyl
oligopeptidase (PO) controls a set of genes that determine sensitivity to lithium.
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl