hydroxylase inhibitors for the treatment of renal anaemia and beyond.
Under normoxic conditions, the a subunit undergoes post-translational modifications and O2-dependent prolyl
hydroxylation, and is degraded via the ubiquitin-proteasome pathway mediated by pVHL (von Hippel-Lindau tumor suppressor protein).
It is an essential co-factor for the two enzymes required for collagen synthesis: prolyl
hydroxylase and lysyl hydroxylase (3)
Under normoxia conditions, HIF-la is regulated by prolyl
hydroxylases (PHDs), which target HIF-la for ubiquitination and proteasomal degradation.
Double knockdown of prolyl
hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction.
hydroxylases (PHDs) are central to hypoxia-sensing that is responsible for regulation of activation of the transcription factor, hypoxia inducible factor (HIF).
CRTAP is required for prolyl
3-hydroxylation and mutations cause recessive osteogenesis imperfecta.
Roxadustat is a hypoxia-inducible factor prolyl
hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation and reducing hepcidin.
As a cofactor of prolyl
hydroxylase is essential in biosynthesis of collagen and elastin .
Under normal oxygen conditions, HIF proteins are low, their levels regulated by an enzyme called prolyl
The research team discovered that oxygen-sensing proteins, called prolyl
hydroxylase domain (PHD) proteins, act within T cells to prevent overly strong immune responses to harmless particles that frequently enter the lung.
The enzymes involved are prolyl
hydroxylases and lysyl hydroxylase and the reactions require [O.