Association between disease-specific quality of life and magnetic resonance imaging outcomes in a clinical trial of prolotherapy
for knee osteoarthritis.
Over the past several years, prolotherapy
has been gaining support as an option for patients with tendinopathies and painful osteoarthritic conditions.
is a therapy that tightens loose ligaments by injecting sugar water or vitamin C into the affected area.
The authors of the review reported that three studies comparing prolotherapy
alone with control injections alone found no evidence for efficacy, while benefits were seen in the two studies that compared prolotherapy
plus other modalities such as spinal manipulation and exercise.
Of the two positive studies, one that induded 79 patients found a greater proportion of patients in the active prolotherapy
group had achieved a decrease of 50% or more in pain or disability 6 months after a series of six weekly injections, compared with patients in the control group, who received injections of xylocaine/saline solution (J.
There are no scientific data or studies on the use of prolotherapy
in migraine and other headaches.
Glucose is currently the hyperosmolar agent of choice of many prolotherapy
practitioners and research supports its efficacy as a cytokine expressant due to its interference with cellular osmolality (28) (29).
Mennati et al., "The effects of prolotherapy
with hypertonic dextrose versus prolozone (intraarticular ozone) in patients with knee osteoarthritis," Anesthesiology and Pain Medicine, vol.
At present, few known regenerative injection-based therapies that have been used in supraspinatus and other tendinosis, in particularly lateral epicondylitis, are platelet rich plasma (PRP), autologous blood, and prolotherapy
. Types of prolotherapy
include dextrose, phenol-glycerineglucose (P2G), and sodium morrhuate.
Patient 5 Patient 6 Demographics Male, 38 y; LBP-Amox Male, 46 y; (sex, age) & /Clav, 100 days Cervicalgia Pain Region- and LBP-Amox/ Treatment Clav 90 days Past Medical Depression, Right Left ankle History knee arthroscopy x 3, fracture, bilateral knee NRSectomy, osteotomies, right septorhinoplasty hand tendon repairs, steroid induced central serous choroid retinopathy Treatment prior Increased Paroxetine, Acetominophen, to antibiotics lumbar facet codeine, NSAIDS radiofrequency denervation, NSAIDS, Capsaicin cream, acetaminophen, bilateral SI joint prolotherapy
, physiotherapy How Long Pain 3 years 7 years Present Location & Type L5/S1 Modic 1 changes C5/6 Modic 1 of Modic Changes Disc herniation L5/S1 changes.
He specializes in sports medicine, chronic pain, regenerative therapy, prolotherapy
and interventional rehabilitation orthopedic medicine.
If initial treatment does not produce the desired effect, second-line treatments include corticosteroid injections (FIGURE 8), prolotherapy
(injection of an irritant, often dextrose; see "Prolotherapy
: Can it help your patient?" J Fam Pract.