In our study, we also evaluated the factors that could affect the SLN detection rate, including age, menopausal status, tumor location, size, primary biopsy method, Ki-67 proliferative index
, breast cancer subtypes and SLN detection technique.
Caption: Figure 9: The Ki-67 proliferative index
is markedly elevated, indicating a high-grade, aggressive lesion (100x original magnification).
The cells are immunoreactive for endothelial markers with high proliferative index
. (1,2,7) Splenic hamartoma is the term used for a nodular lesion of the spleen, composed of unorganized vascular channels of varying width, with intervening red pulp-like disorganized stroma with or without lymphoid follicles.
There was no correlation between Ki67 proliferative index
with response to preoperative chemoradiotherapy and prognosis .
(A) Hematoxylin & eosin stain section showing fascicles of spindle cells with marked nuclear atypia and pleomorphism, (B) High power view showing atypical nuclei and a mitotic figure (arrow), (C) Immunohistochemical stain for desmin showing strong positivity, (D) Ki67 stain showing high proliferative index
The proliferative index
for doxorubicin group from MCF7/DOX xenograft (0.76 [+ or -] 0.08, Fig.
The proliferative index
was calculated from the data in the histograms considering that two cells with a given CFSE intensity were produced by mitosis of a single cell, possessing a CFSE intensity immediately above, using the following formula (17): proliferative index
= (100-Y)/Y, where Y(%) = X0 + X1/2 + X2/4 + X3/8 + X4/16 + X5/32 + X6/64 + X7/128, X0 represents the percentage of T cells that did not divide (located at M1), and X1-7 represents the peak of gradual division (located from M2 to M7).
Rosa and coworkers  previously demonstrated the ability of adrenaline to increase the proliferative index
of mesenteric lymphocytes and to concomitantly augment the maximal activities of HK, GLUTase, and CS, as well as glucose and glutamine consumption.
Ki67 was positive, showing high proliferative index
The Ki-67, a monoclonal antibody, a protein encoded by M ki-67 gene in humans is a proliferative index
marker, which has emerged as a immunohistochemistry marker with a strong potential to forecast and predict the behavior of MEC by indicating its proliferative capacity9,10,11.
(7), (8) Of the RCC marker antigens, such as inhibin, WT-1, c-kit (CD117), S-100 protein, and CK20, no positive staining was detected for any of the three components of the tumor (i.e., smooth muscle tissue, blood vessels and mature adipose tissue), and a low proliferative index
value was detected according to Ki67 labeling.