These included proliferative phase,disordered proliferative endometrium
,irregular maturation of endometrium, discordance between stroma and glands, simple hyperplasia and complex hyperplasia (table 2).
Frequency and percentages were calculated for marital status, parity and morphological patterns, including proliferative endometrium
, secretory endometrium, endometrial hyperplasia with and without atypia and chronic endometritis.
An overall increase in the endometrial gland density, seen in most tissue present, with a lower volume percentage of stroma is the defining feature that separates disordered proliferative endometrium
Cyclin D1 staining was evaluated in the glandular epithelium component and in the superficial epithelium component (except carcinoma cases) in each group of proliferative endometrium
, secretory endometrium, simple hyperplasia, complex hyperplasia, and adenocarcinoma.
This may be because cases which were reported as simple hyperplasia on D&C were completely removed during curettage leaving behind the basal endometrium only, which was then reported as proliferative endometrium
due to short time gap between the two procedures.
In this study proliferative endometrium
accounts for about 30% cases, whereas in other studies it accounts for about 33% and 32%.
of P Cases Mean SD Value p53 glandular Proliferative endometrium
10 0.00 0.00 .000(*) Secretory endometrium 10 0.00 0.00 Atypical endometrial hyperplasia 10 65.40 108.10 .001([dagger]) Endometrial carcinoma 40 430.60 387.33 .001([double dagger]) p53 stroma Proliferative endometrium
10 0.00 0.00 .001(*) Secretory endometrium 10 0.00 0.00 Atypical endometrial 10 7.90 16.79 .001([dagger]) hyperplasia Endometrial carcinoma 40 54.80 47.56 .00([double dagger]) (*) Significance between proliferative endometrium
and atypical endometrial hyperplasia.
Out of the 556 functional cases of AUB, proliferative endometrium
was the most common seen in 361 cases (50.48%) followed by secretory endometrium seen in 175 cases (24.47%).
Using a monoclonal antibody, we detected CD117 expression in a high percentage of benign endometrium, with the most intense immunostaining in hyperplastic and proliferative endometrium
. Our study also demonstrates that CD117 is expressed in a subset of endometrial carcinomas using both immunohistochemistry and Western blot analyses.
Disordered proliferative endometrium
was seen in 11 (15.4%) patients, 01 (1.4%) showed simple hyperplasia with atypia, 02 (2.8%) were complex hyperplasia with atypia, Hormone effect endometrium was seen in 04 (5.6%) and Products of conception were present in 03 (4.2%).
Majority of the hypothyroid patients, that is 28 out of 45 had proliferative endometrium
as the histological diagnosis on doing fractional curettage.
Endometrial biopsy could be performed in 68 cases, in primary infertility group, 24 (48%) had secretory, 16 (32%) had proliferative endometrium
while 2 (4%) cases had tubercular endometrium whereas in secondary infertility group, 18 (60%) had secretory endometrium and 8 (26.7%) had proliferative endometrium