proliferating cell nuclear antigen


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Related to proliferating cell nuclear antigen: PCNA

proliferating cell nuclear antigen (PCNA),

[MIM*176740]
a nuclear nonhistone protein with a molecular weight of 36-kD that plays a role in the initiation of cell proliferation by augmenting DNA polymerase; stains for proliferating cell nuclear antigen in tumors correlated with grade and mitotic activity.

PCNA

A gene on chromosome 20pter-p12 that encodes a homotrimeric nuclear protein that is a cofactor of DNA polymerase delta. PCNA is ubiquinated in response to DNA damage and is involved in RAD6-dependent DNA repair.

pro·lif·er·at·ing cell nu·cle·ar an·ti·gen

(prō-lif'ĕr-āt'ing sel nū'klē-ĕr an'ti-jen)
A nuclear nonhistone protein with a molecular weight of 36 kD that plays a role in the initiation of cell proliferation by augmenting DNA polymerase; stains for proliferating cell nuclear antigen in tumors correlate with grade and mitotic activity.

proliferating cell nuclear antigen

Abbreviation: PCNA
A protein complex released by cells actively synthesizing DNA. In the blood, PCNAs can be used as markers of disease activity in autoimmune and inflammatory illnesses, malignancies, and other conditions marked by rapid cell replication.
See also: antigen
References in periodicals archive ?
The proliferating cell nuclear antigen (PCNA) gene family in Zea mays is composed of two members that have similar expression programmes.
Viral proliferating cell nuclear antigen of cycling and no cycling cells in synchronized pea roots tips.
The proliferating cell nuclear antigen (PCNA) is a nuclear polypeptide essential for DNA synthesis and replication of mammalian cells.
Preoperatively irradiated rectal carcinoma: analysis of the histopathologic response and predictive value of proliferating cell nuclear antigen immunostaining.
Proliferating cell nuclear antigen and p53 indexes were defined as the percentage of cells showing positive nuclear staining with PCNA or p53, respectively.
Highly aggressive behavior and poor prognosis of small cell carcinoma in the alimentary tract: flow cytometric analysis and immunohistochemical staining for the p53 protein and proliferating cell nuclear antigen.
As an alternative, a very promising noncommercial method, based on microwave heating (MWH) treatment, has recently been reported to achieve the same performance with intracellular targets [CD68, proliferating cell nuclear antigen (PCNA), Ki-67] (2).
A comparison of proliferation markers and their prognostic value for women with endometrial carcinoma, Ki-67, proliferating cell nuclear antigen, and flow cytometric S-phase fraction.
Cell proliferation markers showed an increased expression of Ki-67 (30% to 60%) and proliferating cell nuclear antigen (60% to 90%).
Studies using proliferating cell nuclear antigen and Ki-67 have been contradictory.