proliferating cell nuclear antigen


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Related to proliferating cell nuclear antigen: PCNA

proliferating cell nuclear antigen (PCNA),

[MIM*176740]
a nuclear nonhistone protein with a molecular weight of 36-kD that plays a role in the initiation of cell proliferation by augmenting DNA polymerase; stains for proliferating cell nuclear antigen in tumors correlated with grade and mitotic activity.

PCNA

A gene on chromosome 20pter-p12 that encodes a homotrimeric nuclear protein that is a cofactor of DNA polymerase delta. PCNA is ubiquinated in response to DNA damage and is involved in RAD6-dependent DNA repair.

pro·lif·er·at·ing cell nu·cle·ar an·ti·gen

(prō-lif'ĕr-āt'ing sel nū'klē-ĕr an'ti-jen)
A nuclear nonhistone protein with a molecular weight of 36 kD that plays a role in the initiation of cell proliferation by augmenting DNA polymerase; stains for proliferating cell nuclear antigen in tumors correlate with grade and mitotic activity.

proliferating cell nuclear antigen

Abbreviation: PCNA
A protein complex released by cells actively synthesizing DNA. In the blood, PCNAs can be used as markers of disease activity in autoimmune and inflammatory illnesses, malignancies, and other conditions marked by rapid cell replication.
See also: antigen
References in periodicals archive ?
Proliferating cell nuclear antigen expression in the survival of astrocytoma patients.
Comparison of proliferating cell nuclear antigen to tritiated thymidine as a marker of proliferating hepatocytes in rats.
Harms reported on 30 patients with infiltrating breast cancers of 0.8-6.0 cm who underwent laser photocoagulation therapy The women subsequently had a lumpectomy or mastectomy permitting pathologic correlation between MRI indications of ablation success and cell death as determined by tissue staining with hematoxylin and eosin and proliferating cell nuclear antigen.
The gastrocnemius of four groups was tested by hematoxylin-eosin staining, proliferating cell nuclear antigen and CD34 immunohistochemistry staining, and myosin ATPase staining.
The impact of 5-azacytidine on placental weight, glycoprotein pattern and proliferating cell nuclear antigen expression in rat placenta.
Aliquots of 50 mg total cell protein were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and analyzed in Western blots using antibodies specificto HMGB1, RAGE, vimentin, E-cadherin, and proliferating cell nuclear antigen (PCNA) as a loading control.
Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly in neonatal mouse ovaries by promoting apoptosis of oocytes (Xu et al., 2011).
Objective: It has been documented that human papilloma virus (HPV) DNA replication requires proliferating cell nuclear antigen (PCNA).
gasseri significantly increased the proliferation of RAW264.7 macrophage cells through an increase in S phase DNA synthesis, which was related to the up-regulation of proliferating cell nuclear antigen (PCNA) and cyclin A.
(3) In contrast to many other cell cycle associated proteins like PCNA (Proliferating Cell Nuclear Antigen), the Ki-67 antigen is consistently absent in quiescent cells and is not detectable during DNA repair processes.