prolactinoma


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prolactinoma

 [pro-lak″tĭ-no´mah]
a pituitary adenoma made up of lactotrophs that secretes excessive amounts of prolactin; this may delay puberty in either sex, cause galactorrhea-amenorrhea syndrome in women, or decrease libido and fertility in men. Called also prolactin cell or prolactin-secreting adenoma and lactotrope or lactotroph adenoma.

pro·lac·tin-·pro·duc·ing ad·e·no·ma

a pituitary adenoma composed of prolactin-producing cells; it gives rise to symptoms of nonpuerperal amenorrhea and galactorrhea (Forbes-Albright syndrome) in women and to impotence in men.
Synonym(s): prolactinoma

prolactinoma

Endocrinology A pituitary tumor more common in Pts < age 40 characterized by an excess secretion of prolactin–tumor size correlates with the prolactin level; smaller tumors, microprolactinomas, are more common in ♀; macroprolactinomas are more common in ♂ and associated with sexual dysfunction; women may become symptomatic while on OCs; menses may stop when OCs are discontinued; prolactinomas may grow during pregnancy and be diagnosed postdelivery. See Prolactin.

pro·lac·tin-pro·duc·ing ad·e·no·ma

(prō-lak'tin-prŏ-dūs'ing ad'ĕ-nō'mă)
A pituitary adenoma composed of prolactin-producing cells; it gives rise to symptoms of nonpuerperal amenorrhea and galactorrhea (Forbes-Albright syndrome) in women and to impotence in men.
Synonym(s): prolactinoma.

prolactinoma

A benign tumour of the PITUITARY GLAND that secretes large quantities of the hormone PROLACTIN. The tumour can cause blindness by pressing on the OPTIC CHIASMA and may be suspected because of unexpected milk production (lactation). Treatment is by surgery or by drugs.
References in periodicals archive ?
Overall majority of pituitary lesions are pituitary prolactinoma. Sparse documentation is available to reflect the estimates of the prevalence of pituitary diseases from Pakistan.
When the cases with a prolactinoma (n=139) were divided into two groups, micro- and macroadenoma, there were no statistically significant differences in terms of age.
Inhibition of SKP2 sensitizes bromocriptine-induced apoptosis in human prolactinoma cells.
First line therapy for all the pituitary adenoma is surgical resection except for prolactinoma which has excellent response to pharmacological therapy.1 Endoscopic transsphenoidal surgery was developed under a minimally invasive surgical strategy.
El panhipopituitarismo es inusual y la sintomatologia que se presenta con mas frecuencia es la diabetes insipida y de forma infrecuente la afectacion del lobulo anterior hipofisiario (6), en el caso de la paciente se evidencio un hipotiroidismo central, hipogonadismo central, hipocortisolismo, diabetes insipida (confirmada por el test de desmopresina y medicion de osmolaridad urinaria), ademas hiperprolactinemia por efecto compresivo metastasico, aunque se resalta que hay reportes de prolactinoma asociado (7).
(1,5) A prolactin level >250 ng/mL is usually indicative of a prolactinoma; however, some medications, such as strong D2 receptor antagonists (eg, risperidone, haloperidol), can cause significant elevation without evidence of prolactinoma.
Ademas se diagnostica una lesion selar, compatible con un macroadenoma hipofisiario, compatible con examenes de laboratorio con un Prolactinoma, que se maneja medicamente.
GEO ID Normal : case Contributor Year 0:10 GSE4237 8 resected human pituitary tumor (1 Hussaini IM 2006 recurrent + 1 nonrecurrent + 1 invasive + 1 noninvasive + 4 undefined) +2 HP75 tumor cell line 0:13 GSE22812 Prolactin pituitary tumors (5 Wierinckx A 2011 noninvasive + 2 invasive + 6 aggressive-invasive) 0:16 GSE46311 16 somatotroph adenoma (also known as Lekva T 2013 growth hormone-producing somatotroph pituitary adenomas) 3:4 GSE36314 4 human prolactinoma Oyesiku NM 2012 3 human normal pituitary 3:7 GSE51618 3 pituitary glands Feng J 2013 7 NFPAs (nonfunctioning pituitary adenomas) (4 noninvasive NFPAs + 3 invasive NFPAs)
Ollero Garcia-Agullo, "Grupo de Trabajo de Neuroendocrinologia de la S [Clinical guidelines for diagnosis and treatment of prolactinoma and hyperprolactinemia]," Endocrinologia y Nutricion, vol.
Giant prolactinoma is defined as a pituitary tumour with a largest diameter of 40 mm or more in any direction with massive extrasellar extension and very high prolactin levels (usually above 1000 [micro]g/L) and no concomitant GH or ACTH secretion [1-4].
Tipos de Diagnosticos Reportados por los Participantes Diagnosticos f % ADD 5 2.8 ADHD 21 11.7 Alzheimer 3 1.7 Amnesia 1 0.6 AVM 1 0.6 Cefaleas 13 7.3 Charcot Marie Tooth 1 0.6 Contusion 1 0.6 Convulsiones 2 1.1 Demencia 1 0.6 Depresion 2 1.1 Derrame Cerebral 7 3.9 Dificultad Concentracion 1 0.6 Dificultades Motoras 3 1.7 Epilepsia 11 6.1 Esclerosis Multiple 47 26.3 Fibromialgia 2 1.1 MCI 1 0.6 Migrana 32 17.9 Mild Brain Injury 1 0.6 Narcolepsia 1 0.6 Neuritis Periferica 1 0.6 Parkinson 7 3.9 Perdida Auditiva Repentina 1 0.6 Problemas Cervicales 1 0.6 Problemas de Memoria 2 1.1 Problemas de Sueno 1 0.6 Prolactinoma 1 0.6 Temblores 1 0.6 Trauma Craneal Derecho 1 0.6 No Contesto 6 3.4 Total 179 100.0 Nota.