PROKR2

(redirected from prokineticin receptor 2)

PROKR2

A gene on chromosome 20p12.3 that encodes the G protein-coupled receptor for prokineticin 2, one of a family of proteins that promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. PROKR2 activation mobilises calcium, stimulates phosphoinositide turnover and activates p44/p42 mitogen-activated protein kinase.
References in periodicals archive ?
Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.
[33] reported EG-VEGF as a factor to strengthen cell invasion ability in colon cancer cell lines, by acting on MMP-2, MMP-7, and MMP-9 via prokineticin receptor 2. Later, Goi and his team defined EG-VEGF and its corresponding receptor PROKR2 as prognostic markers in colorectal carcinoma [34, 35] suggesting a common pathway with VEGF sustained by their finding regarding the enhancement of antitumor effects when it was simultaneously targeting VEGF and EG-VEGF [36].
A comparative phenotypic study of kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes.