Erythromycin is not only an antibiotic, but also a gastric prokinetic drug
. It is a motilin receptor agonist which can promote motilin secretion and thereby enhance the gastric emptying .
Famotidine is widely used as competitive [H.sub.2] receptor antagonist ([H.sub.2]RA) and prokinetic drug
Metoclopramide is a commonly used prokinetic drug
in the ICU.
In a recent study from Japan, it was reported that itopride, a prokinetic drug
with antidopamine effect, might be useful in alleviating nausea .
Antonelli, "Effect of a novel prokinetic drug
, R093877, on gastrointestinal transit in healthy volunteers," Gut, vol.
Levosulpiride is a new prokinetic drug
. Levosulpiride is the levorotatory enantiomer of sulpiride and it is a substituted benzamide, has very recently been launched in India.
The herbal formula performed as well as the prokinetic drug
for functional dyspepsia and was superior to metoclopramide in a retrospective cohort study of 961 patients.
The prokinetic drug
class includes substituted benzamides, such as metoclopramide (methoxy-2-chloro-5-procainamide) and bromopride (4-amino-5bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide), which act as dopamine antagonists.
The search terms used included nonulcer, dyspepsia, functional dyspepsia, NUD, indigestion, acotiamide, Z-338, YM443, prokinetic drug
, and randomized controlled trials.
Metoclopramide, a prokinetic drug
used for more than 40 years to treat nausea and vomiting due to various causes, is one alternative to the doxylamine-pyridoxine combination.
A randomised clinical trial comparing the efficacy of a herbal preparation STW5 with the prokinetic drug
cisaprid in patients with dysmo-tility type of functional dyspepsia.
Metoclopramide is another popular prokinetic drug
that hastens stomach emptying of solid and liquid meals into the small intestines.