proinsulin


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Related to proinsulin: proinsulin C-peptide

proinsulin

 [pro-in´soo͡-lin]
a precursor of insulin, having low biologic activity.

pro·in·su·lin

(prō-in'sŭ-lin),
A single-chain precursor of insulin.

proinsulin

/pro·in·su·lin/ (-in´su-lin) a precursor of insulin, having low biologic activity.

proinsulin

(prō-ĭn′sə-lĭn)
n.
A single-chain polypeptide that is the precursor of insulin, converted into insulin by enzymatic action.

proinsulin

[prō·in′s(y)əlin]
Etymology: L, pro + insula, island
a single-chain peptide molecule that is a precursor of insulin.

INS

A gene on chromosome 11p15.5 that encodes preproinsulin, which is cleaved post-translationally into the B- and A-chain peptides (which are covalently linked via two disulfide bonds to form insulin) and C-peptide. Insulin reduces blood glucose and increases cell permeability to monosaccharides, amino acids and fatty acids, and accelerates glycolysis, the pentose phosphate cycle and glycogen synthesis in the liver.

pro·in·su·lin

(prō-in'sŭ-lin)
A single-chain precursor of insulin.

proinsulin

a precursor of insulin, having low biological activity.
References in periodicals archive ?
Insulin and total proinsulin concentration were measured by Sandwich enzyme immunoassay method.
Proinsulin will be disintegrated to proinsulin like molecules (PLMs) in the plasma by proteases (13), (14).
Claim 5 reads: "A DNA transfer vector comprising a deoxynucleotide sequence coding for human proinsulin consisting essentially of a plus strand having the sequence: [nucleotides that encode human proinsulin, described in structural terms].
The shows that certain insulin gene mutations involved in neonatal diabetes cause a portion of the proinsulin proteins in the pancreas' beta cells to misfold.
Phase I studies have been completed or are nearing completion for a proinsulin peptide C 19-A3, an insulin peptide with incomplete Freund adjuvant, and a plasmid encoding proinsulin.
Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans.
The C domains are analogous in location to the C-domain of proinsulin, but are not spliced out from the mature molecule, as it happens during proinsulin processing.
At the cellular level, GLP-1 stimulates proinsulin gene expression and proinsulin biosynthesis, actions that are most likely mediated by cyclic adenosine monophosphate (cAMP).
Following 16 weeks of progressive resistance training, HIV-positive men had a reduction in serum triglyceride levels, but no effect was seen on levels of relevant markers including total cholesterol, HDL cholesterol, LDL cholesterol, insulin, C-peptide, proinsulin, or glucagon.
The method involves delivering into the subject a genetic construct comprising a coding sequence for a human proinsulin operably connected a promoter functional in the host cells.
C-peptide is the fragment left when proinsulin is cleaved to create insulin, Dr.