proinflammatory cytokine


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proinflammatory cytokine

Any of the circulating substances in the blood that deplete lean body mass in critical illness. They include several interleukins (IL-1, IL-6, and IL-8) and tumor necrosis factor.
See also: cytokine
References in periodicals archive ?
Levels of Circulating Proinflammatory Cytokines after DEP Treatment in Mice with Lung Epithelial Cell-Specific IKK2 Deficiency
(10,11) Given the mucoxin potent as an anti cancer, it is interesting to assess its ability, to reduce proinflammatory cytokines that promote growth and metastasis in breast cancer.
In contrast, miR-27a suppression aggravated TNF-[alpha]-induced inflammatory injury, as miR-27a inhibitor affected cell viability, BrdU incorporation, apoptosis, and the release of proinflammatory cytokines resulted in the opposite impacts.
It is suggested that EHH and EHK might contain flavonolignan-like compounds that inhibit the proinflammatory cytokine secretion of PBMCs.
Another important proinflammatory cytokine elevated in leptospirosis is TNF-[alpha] which is generated predominantly from activated macrophages and also from nonimmune cells.
After pain is present, there are two mechanisms of action that may be involved in an analgesia mechanism: (i) nociception blockade that reduces the production of proinflammatory cytokines or (ii) a reduction of proinflammatory cytokines that decreases pain intensity [14, 19, 21].
Five hours later, a combination of branched microglia and amoeboid microglia can be seen coinciding with the peak of proinflammatory cytokine production.
Ferrous myoglobin-induced proinflammatory cytokine excretion in RAW264.7 cells was suppressed by CLI-095 and PDTC, respectively ( P < 0.01).
In our study, we observed that baicalin attenuated proinflammatory cytokine production and also associated brain edema (Figure 7).
These proinflammatory cytokines, which are crucial for numerous immune processes, are majorly regulated by NF-[kappa]B.