Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases
in the regulated secretory pathway.
Chretien, "Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets," Endocrinology, vol.
Cleavage is initiated at two conserved dibasic sites and involves the two endoproteases prohormone convertase 2 (PC2) and prohormone convertase 1/3 (PC1/3) and the carboxypeptidase E (CPE), which are the same enzymes that process proinsulin to mature insulin [24-27].
Verchere, "Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death," Diabetes, vol.
Other candidate genes affected by opioid use that could mediate behaviors such as food intake are the CRE-dependent processing enzymes (prohormone convertases 1/3 and 2) [38, 39] that control the ratio of prohormone to active hormone.
Van De Ven, "Regulation of human prohormone convertase 2 promoter activity by the transcription factor EGR-1," Biochemical Journal, vol.
These granules contain pro-insulin-zinc hexamers which are further processed into mature insulin and C-peptide by the prohormone convertases
PC1/3 and PC2.
However, other endoproteases, such as corin (9, 10), or prohormone convertases
(11) may be involved in the posttranslational maturation of pro[BNP.sub.1-108].
A well-established family of intracellular processing enzymes involved in prohormone maturation is the prohormone convertases (PCs).
 Nonstandard abbreviations: ANP, atria] (A-type) natriuretic peptide; BNP, brain (B-type) natriuretic peptide; proANP and proBNP, propeptides of A- and B-type natriuretic peptide, respectively; and PC, prohormone convertase.