PCSK5

(redirected from prohormone convertase 5)

PCSK5

A gene on chromosome 9q21.3 that encodes a broadly active endoprotease of the peptidase S8 family involved in the constitutive and regulated secretory pathway. It cleaves the RX(K/R)R consensus motif and plays an essential role in establishing pregnancy through the proteolytic activation of key factors, such as BMP2 and CALD1.
References in periodicals archive ?
Whilst prohormone convertase 1 has been implicated in the activation of NTS from its precursors in the GI tract, NTS appears to be derived from its precursor proneurotensin/neuromedian N via prohormone convertase 5 in CRC cell lines [18, 19].
Members of the family of eucaryotic, subtilisin-like endoproteases that reside in the constitutive secretory pathway, which include furin, Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4), Prohormone Convertase 5 (PC5), and Prohormone Convertase 7 (PC7), are prime candidates for the endoproteolytic maturation of pro-BACE.