prohormone


Also found in: Dictionary, Encyclopedia, Wikipedia.

prohormone

 [pro-hor´mōn]
a precursor of a hormone, such as a polypeptide that is cleaved to form a shorter polypeptide hormone or a steroid that is converted to an active hormone by peripheral metabolism. Called also prehormone.

pro·hor·mone

(prō-hōr'mōn),
1. An intraglandular precursor of a hormone; for example, proinsulin. Compare: prehormone.
2. Obsolete term formerly used to designate a substance developed in serum that antagonizes a specific antihormone, and thus enhances the action of the corresponding hormone.

prohormone

(prō-hôr′mōn′)
n.
An inactive compound that is converted by enzymes into a biologically active hormone.

pro·hor·mone

(prō-hōr'mōn)
An intraglandular precursor of a hormone, e.g., proinsulin.
Compare: prehormone, bioregulator

pro·hor·mone

(prō-hōr'mōn)
Intraglandular precursor of a hormone; e.g., proinsulin.
References in periodicals archive ?
Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction.
Decreased expression of CYP27B1 and VDR, which we established, is most likely a consequence of vitamin D deficiency and inadequate production of the 25OHD prohormone in the liver of diabetic animals.
From diarrhea to obesity in prohormone convertase 1/3 deficiency: age-dependent clinical, pathologic, and enteroendocrine characteristics.
It is a prohormone. Its two forms are vitamin D2 and vitamin D31.
Various forms of the vitamin D prohormone reduced sunburn and lowered incidence of tumor development in a mouse model.
This strongly suggests that the tetradecapeptide form of SS is not the mature peptide (Quan et al., 2013).The PSSs of Scylorhinus canicula exhibit extra prohormone convertase consensus cleavage sites, possibly yielding N-terminally-extended forms.
Whilst prohormone convertase 1 has been implicated in the activation of NTS from its precursors in the GI tract, NTS appears to be derived from its precursor proneurotensin/neuromedian N via prohormone convertase 5 in CRC cell lines [18, 19].
In fact, POMC neurons in the ARC of the hypothalamus and the NTS express prohormone convertase 2, which cleaves ACTH and [beta]-LPH to generate a-MSH/CLIP and [gamma]-LPH/[beta]-MSH/[beta]-endorphin, respectively [9].
Proinsulin is a prohormone with low metabolic activity compared to mature insulin.
In addition, the Trop-I, CK-MB, ALT, AST, BUN, Cr, calcium, and N-terminal prohormone of brain natriuretic peptide levels were significant factors that indicated the need for ECMO management.
N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) was 27523 pg/mL upon admission.