prohormone

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prohormone

[pro-hor´mōn]

a precursor of a hormone, such as a polypeptide that is cleaved to form a shorter polypeptide hormone or a steroid that is converted to an active hormone by peripheral metabolism. Called also prehormone.

pro·hor·mone

(prō-hōr'mōn),

1. An intraglandular precursor of a hormone; for example, proinsulin. Compare: prehormone.

2. Obsolete term formerly used to designate a substance developed in serum that antagonizes a specific antihormone, and thus enhances the action of the corresponding hormone.

Farlex Partner Medical Dictionary © Farlex 2012

prohormone

(prō-hôr′mōn′)

An inactive compound that is converted by enzymes into a biologically active hormone.

pro·hor·mone

(prō-hōr'mōn)

An intraglandular precursor of a hormone, e.g., proinsulin.
Compare: prehormone, bioregulator

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

pro·hor·mone

(prō-hōr'mōn)

Intraglandular precursor of a hormone; e.g., proinsulin.

Medical Dictionary for the Dental Professions © Farlex 2012

References in periodicals archive ?

Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction.

Role of Soluble ST2 Levels and Beta-Blockers Dosage on Cardiovascular Events of Patients with Unselected ST-Segment Elevation Myocardial Infarction

Decreased expression of CYP27B1 and VDR, which we established, is most likely a consequence of vitamin D deficiency and inadequate production of the 25OHD prohormone in the liver of diabetic animals.

Effects of Cholecalciferol on Key Components of Vitamin D- Endo/Para/Autocrine System in Experimental Type 1 Diabetes

From diarrhea to obesity in prohormone convertase 1/3 deficiency: age-dependent clinical, pathologic, and enteroendocrine characteristics.

Long-Term Follow-up of a Case with Proprotein Convertase 1/3 Deficiency: Transient Diabetes Mellitus with Intervening Diabetic Ketoacidosis During Growth Hormone Therapy

It is a prohormone. Its two forms are vitamin D2 and vitamin D31.

IMPACT OF VITAMIN D ON DEVELOPMENT OF EARLY CHILDHOOD CARIES

Various forms of the vitamin D prohormone reduced sunburn and lowered incidence of tumor development in a mouse model.

Is Moderate Sun Exposure Healthy?

This strongly suggests that the tetradecapeptide form of SS is not the mature peptide (Quan et al., 2013).The PSSs of Scylorhinus canicula exhibit extra prohormone convertase consensus cleavage sites, possibly yielding N-terminally-extended forms.

Characterization, Tissue-Specific and Developmental Stage Expression of Somatostatin in Coilia nasus

Whilst prohormone convertase 1 has been implicated in the activation of NTS from its precursors in the GI tract, NTS appears to be derived from its precursor proneurotensin/neuromedian N via prohormone convertase 5 in CRC cell lines [18, 19].

A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer

In fact, POMC neurons in the ARC of the hypothalamus and the NTS express prohormone convertase 2, which cleaves ACTH and [beta]-LPH to generate a-MSH/CLIP and [gamma]-LPH/[beta]-MSH/[beta]-endorphin, respectively [9].

Glucose Intake Alters Expression of Neuropeptides Derived from Proopiomelanocortin in the Lateral Hypothalamus and the Nucleus Accumbens in Fructose Preference Rats

Proinsulin is a prohormone with low metabolic activity compared to mature insulin.

Proinsulin Promotes Self-Renewal of a Hematopoietic Progenitor Cell Line In Vitro

In addition, the Trop-I, CK-MB, ALT, AST, BUN, Cr, calcium, and N-terminal prohormone of brain natriuretic peptide levels were significant factors that indicated the need for ECMO management.

Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis

N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) was 27523 pg/mL upon admission.

Antiproteinase 3 Positive Eosinophilic Granulomatosis with Polyangiitis Presenting with Heart Failure and Intraventricular Thrombosis