BNP is synthesized in the form of a
prohormone, BNP precursor (proBNP), which consists of 108 amino acid residues (aar) (1).
2]; Lp(a), lipoprotein a; ApoA1, apolipoprotein A-I; ApoB, apolipoprotein B-100; apo(a), apolipoprotein(a); WHS, Women's Health Study; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal
prohormone of BNP; CHS, Cardiovascular Health Study; DHS, Dallas Heart Study; SNP, single-nucleotide polymorphism; CAC, coronary artery calcification.
1] Nonstandard abbreviations: NT-proBNP, N-terminal
prohormone of brain natriuretic peptide; HD, hemodialysis; RCV, reference change value; CVa, analytical variation; CVi, within-person biological variation; CVb, between-person biological variation; II, index of individuality.
4] Nonstandard abbreviations: cTnT, cardiac troponin T; cardiac troponin T-I-C complex, cTnT, cTnI, and TnC; AMI, acute myocardial infarction; GFC, gel filtration chromatography; STEMI, ST-segment elevation myocardial infarction; PCI, percutaneous coronary intervention; CK, creatine kinase; LD, lactate dehydrogenase; NT-proBNP, N-terminal fragment of the
prohormone brain-type natriuretic peptide; [V.
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Because cardiac myocytes possess a biosynthetic apparatus, including enzymes for elaborate propeptide processing, cardiac
prohormone maturation has proven to be much more complex than initially assumed.
It's sometimes referred to as a
prohormone and can be considered the "mother" of all the steroid hormones.
Furthermore, after adjustment was made for subject age, gender,
prohormone brain natriuretic peptide levels, and ejection fraction at recruitment, there was a 76% relative risk reduction in heart failure with the intensified strategy versus conventional treatment.
Chromogranin A processing and secretion: specific role of endogenous and exogenous
prohormone convertases in the regulated secretory pathway.
Vitamin D
prohormone in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease.
The updated guideline acknowledges Rayaldee (extended release calcifediol) as a novel vitamin D
prohormone and mentions that it both increases serum levels of 25-hydroxyvitamin D and lowers PTH in patients with stage 3 or 4 CKD.
Various forms of the vitamin D
prohormone reduced sunburn and lowered incidence of tumor development in a mouse model.
