BNP is synthesized in the form of a prohormone
, BNP precursor (proBNP), which consists of 108 amino acid residues (aar) (1).
2]; Lp(a), lipoprotein a; ApoA1, apolipoprotein A-I; ApoB, apolipoprotein B-100; apo(a), apolipoprotein(a); WHS, Women's Health Study; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal prohormone
of BNP; CHS, Cardiovascular Health Study; DHS, Dallas Heart Study; SNP, single-nucleotide polymorphism; CAC, coronary artery calcification.
1] Nonstandard abbreviations: NT-proBNP, N-terminal prohormone
of brain natriuretic peptide; HD, hemodialysis; RCV, reference change value; CVa, analytical variation; CVi, within-person biological variation; CVb, between-person biological variation; II, index of individuality.
4] Nonstandard abbreviations: cTnT, cardiac troponin T; cardiac troponin T-I-C complex, cTnT, cTnI, and TnC; AMI, acute myocardial infarction; GFC, gel filtration chromatography; STEMI, ST-segment elevation myocardial infarction; PCI, percutaneous coronary intervention; CK, creatine kinase; LD, lactate dehydrogenase; NT-proBNP, N-terminal fragment of the prohormone
brain-type natriuretic peptide; [V.
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Because cardiac myocytes possess a biosynthetic apparatus, including enzymes for elaborate propeptide processing, cardiac prohormone
maturation has proven to be much more complex than initially assumed.
It's sometimes referred to as a prohormone
and can be considered the "mother" of all the steroid hormones.
Furthermore, after adjustment was made for subject age, gender, prohormone
brain natriuretic peptide levels, and ejection fraction at recruitment, there was a 76% relative risk reduction in heart failure with the intensified strategy versus conventional treatment.
Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone
convertases in the regulated secretory pathway.
Vitamin D prohormone
in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease.
The updated guideline acknowledges Rayaldee (extended release calcifediol) as a novel vitamin D prohormone
and mentions that it both increases serum levels of 25-hydroxyvitamin D and lowers PTH in patients with stage 3 or 4 CKD.
Various forms of the vitamin D prohormone
reduced sunburn and lowered incidence of tumor development in a mouse model.