progressive vaccinia


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vaccinia

 [vak-sin´e-ah]
the cutaneous and sometimes systemic reactions associated with vaccination with smallpox vaccine. See also cowpox and paravaccinia.
vaccinia gangreno´sa generalized vaccinia with failure to develop antibodies against the virus (due to agammaglobulinemia), with spreading necrosis at the site and metastasis of lesions throughout the body.
generalized vaccinia a condition of widespread vaccinial lesions resulting from sensitivity response to smallpox vaccination and delayed production of neutralizing antibodies.
progressive vaccinia vaccinia gangrenosa.

pro·gress·ive vac·cin·i·a

a severe or even fatal form of vaccinia occurring chiefly in patients with an immunologic deficiency or dyscrasia and characterized by progressive enlargement of the initial and also of secondary lesions.
Synonym(s): vaccinia gangrenosa

vaccinia

(vak-sin'e-a) [ vaccine + -ia],

VV

A contagious disease of cattle, produced in humans by inoculation with cowpox virus to confer immunity against smallpox. Papules form about the third day after vaccination, changing to umbilicated vesicles about the fifth day, and at the end of the first week becoming umbilicated pustules surrounded by red areolae. They dry and form scabs, which fall off about the second week, leaving a white pitted depression. Synonym: cowpox; vaccina See: vaccination; varicella; variola

vaccinia necrosum

Spreading necrosis at the site of a smallpox vaccination; may be accompanied by similar necrotic areas elsewhere on the body.
Synonym: progressive vaccinia

progressive vaccinia

vaccinia necrosum.
References in periodicals archive ?
On day 12, in an attempt to reduce viral replication and prevent progressive vaccinia, a second 6,000 IU/kg dose of VIGIV was administered along with the investigational antiviral agent, ST-246 (SIGA Technologies, Corvalis, Oregon).
The improvement of progressive vaccinia in this patient was associated with receipt of VIGIV (the only licensed product for treatment of vaccinia adverse events stockpiled by the SNS), ST-246, and CMX001, and an increase in lymphocyte count.
new cases (May 10-June 20) Adverse events Suspected + Probable (ss) Eczema vaccinatum -- ** -- Fetal vaccinia -- -- Generalized vaccinia 1 -- Inadvertent inoculation, nonocular 1 -- Ocular vaccinia -- -- Progressive vaccinia -- -- Erythema multiforme major -- -- (Stevens-Johnson syndrome) Myo/pericarditis 2 2 Post vaccinial encephalitis or -- -- encephalomyelitis Pyogenic infection of vaccination site -- -- No.
new cases (April 5-13) Adverse events Suspected + Probable (ss) Eczema vaccinatum -- ** -- Erythema multiforme major (Stevens- -- -- Johnson syndrome) Fetal vaccinia -- -- Generalized vaccinia 1 -- Inadvertent inoculation (nonocular) 7 -- Myocarditis/Pericarditis 3 -- Ocular vaccinia -- -- Postvaccinial encephalitis or -- -- encephalomyelitis Progressive vaccinia -- -- Pyogenic infection of vaccination -- -- site No.
new cases (March 31-April 4) Adverse events Suspected + Probable (ss) Confirmed (n) Eczema vaccinatum -- ** -- -- Erythema multiforme major -- -- NA ++ (stevens-Johnson syndrome) Fetal vaccinia -- -- -- Generalized vaccinia -- -- -- Inadvertent inoculation, 5 -- -- nonocular Myocarditis/pericarditis 2 1 -- Ocular vaccinia -- -- -- Postvaccinial encephalitis or -- -- NA encephalomyelitis Progressive vaccinia -- -- -- Pyogenic infection of -- -- -- vaccination site Total no.
progressive vaccinia, eczema vaccinatum, post-vaccinial encephalitis, or encephalomyelitis) have been reported among civilians.
new cases (March 4-10) Potentially life-threatening events Eczema vaccinatum -- + -- Erythema multiforme major (Stevens-Johnson syndrome) -- -- Fetal vaccinia -- -- Post-vaccinial encephalitis or encephalomyelitis -- -- Progressive vaccinia -- -- Moderate-to-severe events (ss) Generalized vaccinia -- -- Inadvertent inoculation, non-ocular 1 2 Ocular vaccinia -- -- Pyogenic infection of vaccination site -- -- Other events of concern No.
new cases (February 25-March 3) Adverse events Suspected Probable Potentially life-threatening events Eczema vaccinatum -- + -- Erythema multiforme major (Stevens-Johnson syndrome) -- -- Fetal vaccinia -- -- Post-vaccinial encephalitis or encephalomyelitis -- -- Progressive vaccinia -- -- Moderate-to-severe events Generalized vaccinia -- -- Inadvertent inoculation, non-ocular -- -- Ocular vaccinia -- 2 (ss) Pyogenic infection of vaccination site -- -- Other events of concern No.
new cases Adverse events Suspected Probable Potentially life-threatening events Eczema Vaccinatum -- + -- Erythema multiforme major (Stevens- Johnson syndrome) -- -- Fetal vaccinia -- -- Post-vaccinial encephalitis or -- -- encephalomyelitis Progressive vaccinia -- -- Moderate-to-severe events Generalized vaccinia 1 -- Inadvertent inoculation, non-ocular -- -- Ocular vaccinia -- -- Pyogenic infection of vaccination site -- -- Other events of concern Other serious adverse events (ss) 1 Other nonserious adverse events (n) 16 Vaccinia immune globulin release -- Vaccinia transmission to contacts -- Total no.
cases Adverse events Suspected Probable Potentially life-threatening events Eczema vaccinatum -- + -- Erythema multiforme major -- -- (Stevens-Johnson syndrome) Fetal vaccinia -- -- Post-vaccinial encephalitis or -- -- encephalomyelities Progressive vaccinia -- -- Moderate-to-severe events Generalized vaccinia -- -- Inadvertent inoculation, non- -- -- ocular Ocular vaccinia -- -- Pyogenic infection of vaccination -- -- site No.
TABLE Adverse events after smallpox vaccination that are recommended to be reported to the Vaccine Adverse Event Reporting System and to state health departments * Eczema vaccinatum Erythema multiforme major or Stevens-Johnson syndrome Fetal vaccinia Generalized vaccinia Inadvertent inoculation Ocular vaccinia Post-vaccinal encephalitis or encephalomyelitis Progressive vaccinia Pyogenic infection of vaccination site Vaccinia transmission to contacts Vaccination of persons with a contraindication to vaccination Other serious adverse events (i.

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