progressive vaccinia


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vaccinia

 [vak-sin´e-ah]
the cutaneous and sometimes systemic reactions associated with vaccination with smallpox vaccine. See also cowpox and paravaccinia.
vaccinia gangreno´sa generalized vaccinia with failure to develop antibodies against the virus (due to agammaglobulinemia), with spreading necrosis at the site and metastasis of lesions throughout the body.
generalized vaccinia a condition of widespread vaccinial lesions resulting from sensitivity response to smallpox vaccination and delayed production of neutralizing antibodies.
progressive vaccinia vaccinia gangrenosa.

pro·gress·ive vac·cin·i·a

a severe or even fatal form of vaccinia occurring chiefly in patients with an immunologic deficiency or dyscrasia and characterized by progressive enlargement of the initial and also of secondary lesions.
Synonym(s): vaccinia gangrenosa

vaccinia

(vak-sin'e-a) [ vaccine + -ia],

VV

A contagious disease of cattle, produced in humans by inoculation with cowpox virus to confer immunity against smallpox. Papules form about the third day after vaccination, changing to umbilicated vesicles about the fifth day, and at the end of the first week becoming umbilicated pustules surrounded by red areolae. They dry and form scabs, which fall off about the second week, leaving a white pitted depression. Synonym: cowpox; vaccina See: vaccination; varicella; variola

vaccinia necrosum

Spreading necrosis at the site of a smallpox vaccination; may be accompanied by similar necrotic areas elsewhere on the body.
Synonym: progressive vaccinia

progressive vaccinia

vaccinia necrosum.
References in periodicals archive ?
On day 12, in an attempt to reduce viral replication and prevent progressive vaccinia, a second 6,000 IU/kg dose of VIGIV was administered along with the investigational antiviral agent, ST-246 (SIGA Technologies, Corvalis, Oregon).
Persons with a history of atopic dermatitis or other active exfoliative skin conditions and those with immune deficiencies or immunosuppressive conditions are at greater risk for adverse outcomes (e.g., eczema vaccinatum and progressive vaccinia) after infections with nonhighly attenuated variants of vaccinia virus (6), including Raboral V-RG (7).
The development of progressive vaccinia, historically observed in patients with cellular immunodeficiencies, often leads to superinfection and subsequent sepsis (i.e., fungal, parasitic, and bacterial infections resulting in toxic or septicemic shock, then ultimately death).
Generalized vaccinia, progressive vaccinia, and eczema vaccinatum are rare following smallpox (vaccinia) vaccination: United States surveillance, 2003.
The latter is the risk, measured in the 1960s, of serious vaccine-related adverse events (e.g., postvaccinial encephalitis and progressive vaccinia) among revaccinees (20,21).
new cases (April 5-13) Adverse events Suspected + Probable (ss) Eczema vaccinatum -- ** -- Erythema multiforme major (Stevens- -- -- Johnson syndrome) Fetal vaccinia -- -- Generalized vaccinia 1 -- Inadvertent inoculation (nonocular) 7 -- Myocarditis/Pericarditis 3 -- Ocular vaccinia -- -- Postvaccinial encephalitis or -- -- encephalomyelitis Progressive vaccinia -- -- Pyogenic infection of vaccination -- -- site No.
new cases (March 31-April 4) Adverse events Suspected + Probable (ss) Confirmed (n) Eczema vaccinatum -- ** -- -- Erythema multiforme major -- -- NA ++ (stevens-Johnson syndrome) Fetal vaccinia -- -- -- Generalized vaccinia -- -- -- Inadvertent inoculation, 5 -- -- nonocular Myocarditis/pericarditis 2 1 -- Ocular vaccinia -- -- -- Postvaccinial encephalitis or -- -- NA encephalomyelitis Progressive vaccinia -- -- -- Pyogenic infection of -- -- -- vaccination site Total no.
As of March 30, no cases of several potentially life-threatening adverse events associated historically with smallpox vaccination (i.e., progressive vaccinia, eczema vaccinatum, post-vaccinial encephalitis, or encephalomyelitis) have been reported among civilians.
new cases (March 4-10) Potentially life-threatening events Eczema vaccinatum -- + -- Erythema multiforme major (Stevens-Johnson syndrome) -- -- Fetal vaccinia -- -- Post-vaccinial encephalitis or encephalomyelitis -- -- Progressive vaccinia -- -- Moderate-to-severe events (ss) Generalized vaccinia -- -- Inadvertent inoculation, non-ocular 1 2 Ocular vaccinia -- -- Pyogenic infection of vaccination site -- -- Other events of concern No.
new cases (February 25-March 3) Adverse events Suspected Probable Potentially life-threatening events Eczema vaccinatum -- + -- Erythema multiforme major (Stevens-Johnson syndrome) -- -- Fetal vaccinia -- -- Post-vaccinial encephalitis or encephalomyelitis -- -- Progressive vaccinia -- -- Moderate-to-severe events Generalized vaccinia -- -- Inadvertent inoculation, non-ocular -- -- Ocular vaccinia -- 2 (ss) Pyogenic infection of vaccination site -- -- Other events of concern No.
cases Adverse events Suspected Probable Potentially life-threatening events Eczema vaccinatum -- + -- Erythema multiforme major -- -- (Stevens-Johnson syndrome) Fetal vaccinia -- -- Post-vaccinial encephalitis or -- -- encephalomyelities Progressive vaccinia -- -- Moderate-to-severe events Generalized vaccinia -- -- Inadvertent inoculation, non- -- -- ocular Ocular vaccinia -- -- Pyogenic infection of vaccination -- -- site No.
TABLE Adverse events after smallpox vaccination that are recommended to be reported to the Vaccine Adverse Event Reporting System and to state health departments * Eczema vaccinatum Erythema multiforme major or Stevens-Johnson syndrome Fetal vaccinia Generalized vaccinia Inadvertent inoculation Ocular vaccinia Post-vaccinal encephalitis or encephalomyelitis Progressive vaccinia Pyogenic infection of vaccination site Vaccinia transmission to contacts Vaccination of persons with a contraindication to vaccination Other serious adverse events (i.e., those resulting in hospitalization, permanent disability, life-threatening illness, or death) * Any adverse event that is of concern to the clinician or patient should be reported.

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