progressive familial intrahepatic cholestasis
Also found in: Dictionary, Thesaurus, Acronyms, Wikipedia.
ABCB11A gene on chromosome 2q24 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, MDR/TAP subfamily, which is involved in multi-drug resistance and is major canalicular bile salt export pump
Molecular pathology ABCB11 mutations cause a type of progressive
familial intrahepatic cholestasis of early (infancy) onset.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
cholestasis, cholestasia (ko?le-sta'sis) (ko?le-sta'zh(e-)a) [ chole- + stasis]
Arrest of the flow of bile. This may be due to intrahepatic causes, obstruction of the bile duct by gallstones, or any process that blocks the bile duct (e.g., cancer). cholestatic (ko?le-stat'ik), adjective
intrahepatic cholestasis of pregnancyAbbreviation: ICP
A complication of approx. 1% of pregnancies in which elevated levels of pregnancy hormones cause obstruction to bile flow within the liver. Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color than normal. ICP increases the risk of preterm delivery of the fetus and of bleeding disorders and loss of life of the fetus. Synonym: obstetric cholestasis
obstetric cholestasisIntrahepatic cholestasis of pregnancy.
progressive familial intrahepatic cholestasisByler disease.
Medical Dictionary, © 2009 Farlex and Partners