M2 PHARMA-May 6, 2019-Context Therapeutics Starts Phase 2 Trial for Apristor in Progesterone Receptor Positive
Patients with estrogen and progesterone receptor positive
breast cancer, the progression of disease process could be controlled by modifying the effects of these hormones.
(7) Because most neuroendocrine breast tumors are estrogen receptor and progesterone receptor positive
, endocrine-based therapy may be an effective treatment strategy.
Of the cancers in transgender women, 82% were estrogen receptor positive, 64% were progesterone receptor positive
, and 9% were Her2/neu positive.
The hormone receptor positive subtype was defined as estrogen receptor and or progesterone receptor positive
and HER2 negative, HER2 ositive subtype as estrogen and or progesterone receptor positive
or negative with HER2 positive, and triple negative subtypes as estrogen receptor, progesterone receptor, and HER2 negative.
The assessment of steroid receptor status showed that 59.2% (122) of patients had both estrogen and progesterone receptor positive
phenotypes, and additionally 19.4% (40) of patients had ER or PR positive steroid receptor status.
Caption: Figure 2: Histology of the tumor: (a) low magnification (x100) showing typical features of meningioma; (b) high magnification (x400) showing some evidence of nuclear atypia; (c) immunohistochemical staining showing the tumor to be progesterone receptor positive
Estrogen receptor negative/ progesterone receptor positive
breast cancer is not a reproducible subtype.
Arno Therapeutics, a company involved in the discovery and development of small molecule drugs, has enrolled its first patient in a Phase I dose escalation trial evaluating onapristone in post-menopausal women with progesterone receptor positive
tumours, including breast, endometrial and other solid tumours, it was reported yesterday.
Kalman et al., "Estrogen receptor negative and progesterone receptor positive
breast carcinomashow frequent are they?" Pathology and Oncology Research, vol.
In addition, there was an elevated risk of estrogen receptor positive and progesterone receptor positive
tumors in Caucasian women related to a 500 gram per week increase in total red meat intake.
Progesterone receptor positive
colorectal tumors have lower thymidine phosphorylase expression: an immunohistochemical study.