(NASDAQ: XBIO) has commenced patient enrollment in its Phase 2 clinical study of XBIO-101 (sodium cridanimod) in conjunction with progestin therapy for the treatment of endometrial cancer in patients who have either failed progestin monotherapy or who have been identified as having progesterone receptor negative
(PrR-) tumors, the company said.
Currently, Virexxa is being studied in an ongoing Phase 2 multi-national study enrolling 58 subjects with documented evidence of progesterone receptor negative
(PrR-negative) endometrial cancer as determined by tumor biopsy in conjunction with Pharmsynthez PJSC (St.
Thus, TNBC tumors are estrogen receptor negative (ER), progesterone receptor negative
(PR), and HER2/neu negative (HER2).
"The other major type of breast cancer is the triple negative, estrogen and progesterone receptor negative
, and HER-2 negative," Shumaker said.
Poultry intake was associated with estrogen receptor negative and progesterone receptor negative
In 32 cases the tumors were progesterone receptor negative (<10% positive nuclear staining) and the Recurrence Scores in 31 of 32 cases ranged form 12 to 50, with a mean Recurrence Score of 28.
In 6 cases, the tumor was both progesterone receptor negative and exhibited a mitotic count score of 3, and in all these cases the Recurrence Score was high.
By the end of the study, 1,021 women had developed breast cancer, including 512 cases that were oestrogen and progesterone receptor positive, 167 that were oestrogen and progesterone receptor negative
, 110 with mixed status and 232 with unknown status.
Thirty-eight point seven percent of the patients were progesterone receptor negative
, with 61.3% being positive.
The women with oestrogen and progesterone receptor negative
status, hormonal therapy will be ineffective.
These results are in line with previous findings that have demonstrated a breast-feeding benefit in triple-negative breast cancer, which includes estrogen and progesterone receptor negative
All the nulliparous patients were Progesterone receptor Negative