antiprogestin

(redirected from progesterone antagonist)

antiprogestin

 [an″te-, an″ti-pro-jes´tin]
a substance that inhibits the formation of progestational agents; the most common example is mifepristone.

an·ti·pro·ges·tin

(an'tē-prō-jes'tin),
A substance that inhibits progesterone formation, that interferes with its carriage or stability in the blood, or that reduces its uptake by, or effects on, target organs (for example, RU486, mifepristone).

antiprogestin

/anti·pro·ges·tin/ (an″te-) (an″ti-pro-jes´tin) a substance that inhibits the formation, transport, or action of progestational agents.

antiprogestin

[-prōjes′tin]
a substance that interferes with the production, uptake, or effects of progesterone. The most common example is mifepristone.

an·ti·pro·ges·tin

(an'tē-prō-jes'tin)
A substance that inhibits progesterone formation, interferes with its carriage or stability in the blood, or reduces its uptake by, or effects on, target organs (e.g., RU-486, mifepristone).
Synonym(s): progesterone antagonist.
References in periodicals archive ?
It is an oral partial progesterone antagonist that exerts a direct effect on the endometrium to control excessive bleeding and on fibroids where it inhibits cell proliferation and induces apoptosis (cell death) to reduce their size.
In vitro studies have demonstrated that the progesterone antagonist induced by aglepristone improves contractile activity of the myometrium induced by prostaglandins (16), which clinically implies assistance in the elimination of pyogenic material in less time, facilitating recuperation.
It was found least effective in cases of closed pyometra (24%), which brought about the use of progesterone antagonists like aglepristone (15,17), which improve efficacy when combined with prostaglandins, above all, in order to carry out therapies in bitches of high economic value and where surgery is not an option (18).
Females treated jointly with progesterone antagonists and natural or synthetic prostaglandins F2[alpha] were 75% of the time cured (11,15,17), while patients that only received prostaglandins only reached 60% (13).
Steinauer of the university Two states - Arizona and Ohio - require that the FDA-approved regimen be used when prescribing the progesterone antagonist mifepristone for abortion, according to the Guttmacher Institute, which seeks to advance reproductive rights.
The progesterone antagonist RU486 (mifepristone) also holds promise.
Mifepristone, a progesterone antagonist that is approved for use with misoprostol to induce abortion, also is a potent glucocorticoid receptor antagonist in doses higher than those used to end pregnancy.
Termination of Early Pregnancy by the Progesterone Antagonist RU 486 (Mifepristone)," New England Journal of Medicine, 315:1565-1570, 1986.
Another approach being developed for patients with high levels of circulating cortisol involves the abortion pill mifepristone, which, in addition to being a progesterone antagonist, also is a glucocorticoid antagonist.
Progesterone antagonists and progesterone receptor modulators: an overview.
Luteal control of endometrial receptivity and its modification by progesterone antagonists.