progeroid

progeroid

(prō-jēr'oyd),
Pertaining to progeria and related conditions involving premature aging.
References in periodicals archive ?
Eiger is preparing an NDA and MAA for lonafarnib to treat Hutchinson-Gilford Progeria Syndrome (HGPS or Progeria) and Progeroid Laminopathies.
David Cory, President and CEO of Eiger, said, 'Eiger's pipeline is now late-stage with planned global regulatory activities including an NDA and MAA for Progeria and Progeroid Laminopathies, enrollment of a global Phase 3 study for Lonafarnib in HDV, and End of Phase 2 meetings for Peginterferon Lambda in HDV and Avexitide in Post-Bariatric Hypoglycemia.
Clinigen Group has partnered with Eiger BioPharmaceuticals to launch a worldwide lonafarnib Managed Access Program for patients with Progeria and Progeroid Laminopathies.
Global Banking News-December 20, 2018-Eiger awarded US FDA's breakthrough therapy designation for lonafarnib for the treatment of Progeria and progeroid laminopathies
Of note, association between accelerated aging and elevated serum phosphate levels is also observed in some patients with Hutchinson-Gilford syndrome, a rare hereditary progeroid disease caused by mutation in the lamin A gene, although high phosphate may not be the primary reason for their premature aging symptoms [14].
The administration and resulting clearance of senescent cells led to enhanced health span and a delay in multiple age-related phenotypes in progeroid mice [51].
Consistently, senolytics treatment has been associated with a plethora of beneficial effects: (1) improved cardiac ejection fraction in old mice; (2) enhanced vascular reactivity in old mice; (3) decreased vascular calcification, increased vascular reactivity, and reduced senescence burden in the plaque of apoE-/mice; (4) decreased frailty, osteoporosis, and loss of intervertebral disc glycosaminoglycans in progeroid mice; (5) decreased gait disturbance in mice after radiation damage to a leg; (6) attenuated haematological dysfunction caused by whole body radiation; (7) increased coat density; and (8) improved pulmonary function and reduced pulmonary fibrosis in mice with bleomycin-induced lung damage [33, 34].
Patients with progeroid syndromes such as mandibuloacral dysplasia, type B (MADB) and restrictive dermopathy (RD) harbor mutations in zinc metalloproteinase (ZMPSTE24), an enzyme essential for posttranslational proteolysis of prelamin A to form mature lamin A.
Raams et al., "A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis," Nature, vol.
Indeed, SIRT6 knockout mouse shows a dramatic aging phenotype and spontaneously develops a progeroid syndrome.