Eiger is preparing an NDA and MAA for lonafarnib to treat Hutchinson-Gilford Progeria Syndrome (HGPS or Progeria) and Progeroid
David Cory, President and CEO of Eiger, said, 'Eiger's pipeline is now late-stage with planned global regulatory activities including an NDA and MAA for Progeria and Progeroid
Laminopathies, enrollment of a global Phase 3 study for Lonafarnib in HDV, and End of Phase 2 meetings for Peginterferon Lambda in HDV and Avexitide in Post-Bariatric Hypoglycemia.
Genomic instability and DNA replication defects in progeroid
Clinigen Group has partnered with Eiger BioPharmaceuticals to launch a worldwide lonafarnib Managed Access Program for patients with Progeria and Progeroid
Global Banking News-December 20, 2018-Eiger awarded US FDA's breakthrough therapy designation for lonafarnib for the treatment of Progeria and progeroid
Of note, association between accelerated aging and elevated serum phosphate levels is also observed in some patients with Hutchinson-Gilford syndrome, a rare hereditary progeroid
disease caused by mutation in the lamin A gene, although high phosphate may not be the primary reason for their premature aging symptoms .
The administration and resulting clearance of senescent cells led to enhanced health span and a delay in multiple age-related phenotypes in progeroid
Consistently, senolytics treatment has been associated with a plethora of beneficial effects: (1) improved cardiac ejection fraction in old mice; (2) enhanced vascular reactivity in old mice; (3) decreased vascular calcification, increased vascular reactivity, and reduced senescence burden in the plaque of apoE-/mice; (4) decreased frailty, osteoporosis, and loss of intervertebral disc glycosaminoglycans in progeroid
mice; (5) decreased gait disturbance in mice after radiation damage to a leg; (6) attenuated haematological dysfunction caused by whole body radiation; (7) increased coat density; and (8) improved pulmonary function and reduced pulmonary fibrosis in mice with bleomycin-induced lung damage [33, 34].
diseases; Nat Rev Mol Cell Biol 8:394; 2007.
Patients with progeroid
syndromes such as mandibuloacral dysplasia, type B (MADB) and restrictive dermopathy (RD) harbor mutations in zinc metalloproteinase (ZMPSTE24), an enzyme essential for posttranslational proteolysis of prelamin A to form mature lamin A.
Raams et al., "A new progeroid
syndrome reveals that genotoxic stress suppresses the somatotroph axis," Nature, vol.
Indeed, SIRT6 knockout mouse shows a dramatic aging phenotype and spontaneously develops a progeroid