and derived lines were homozygous at most loci with the exception of line K230, which was found to be heterozygous at 47 out of the 105 marker loci (data not shown).
The hypothesis is that epithelial progenitor
cells derived from bone marrow have a role in ongoing endothelial repair and that impaired mobilization or depletion of these cells contributes to endothelial dysfunction and cardiovascular disease progression.
"Using a technique called fluorescence-activated cell sorting, we can actually sort these oligos we've removed from healthy rats into either progenitors
or mature cells.
These neurons are generated by progenitor
cells, which produce them one after the other in a very precise order.
According to the Boston Children's Hospital, progenitor
cells, not to be confused with adult stem cells, are defined as "early descendents of stem cells that can differentiate to form one or more kinds of cells, but cannot divide and reproduce indefinitely." Progenitor
cells are therefore more limited than stem cells in the types of cells they can form, but still have potential applications in medicine.
Research previously showed that the numbers of progenitor
cells are also diminished in organs that shrink with age.
Frequency will use the proceeds to support the clinical development of FX-322, a regenerative therapeutic for the treatment of sensorineural hearing loss that is moving into a Phase 2a study, and to advance discovery programmes in other therapeutic areas using its proprietary Progenitor
Cell Activation platform.
Building on previous research by Nakano, which showed that the embryonic heart tube produces blood progenitor
cells, the new study found that those cells, in turn, generate specialized immune cells called macrophages.
(CBMG) announced that its off-the-shelf allogeneic adipose-derived mesenchymal progenitor
cell (haMPC, "AlloJoin") therapy for knee osteoarthritis (KOA) has been approved as the first stem cell KOA drug application in China for a Phase 2 clinical trial.
AML is a hematologic malignancy characterized by the accumulation of clonal myeloid progenitor
cells in the blood or bone marrow.
Scientists from the University of Copenhagen in Denmark and the Helmholtz Zentrum Mnchen in Neuherberg, Germany have mapped the signals that determine the destiny of progenitor
cells in the pancreas.
This NMPA's approval for Melphalan Hydrochloride For Injection (EVOMELA) is indicated as a high-dose conditioning treatment prior to hematopoietic progenitor
(stem) cell transplantation in patients with multiple myeloma and the palliative treatment of patients with multiple myeloma for whom oral therapy is not appropriate.