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A small protein that binds to monomeric actin (thus becoming profilactin), preventing premature polymerization of actin. It also participates in the inhibition of one isoform of phospholipase C.
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References in periodicals archive ?
Ortaya cikan spektral profilin bilgisayar yardimiyla analizi sayesinde bakteri idantifikasyonuna gidilmektedir (39).
MontanideTM IMS 1313 N VG PR nanoparticle adjuvant enhances antigen-specific immune responses to profilin following mucosal vaccination against Eimeriaacervulina.
reported in a ROC curve analysis that a panel consisting of 5 proteins (M2BP, MRP14, CD59, catalase, and profilin) had a sensitivity of 90% and a specificity of 83% in the diagnosis of the OSCC via LC-MS/MS [155].
Golenbock, "Of mice and man: TLR11 (finally) finds profilin," Trends in Immunology, vol.
Our previous studies showed that immunization of broilers at day 18 of embryogenesis with the Eimeria recombinant profilin protein induced protection against post-hatch challenge infection with live parasites [19,20].
This could be explained by the fact that sensitization to pollen of date palm in the Mediterranean is an expression of a pan allergen sensitization which is probably a profilin [8].
The functions and interactions of Piccolo include (a) actin cytoskeleton dynamic (profilin, Daam1, Abp1, and GIT1), (b) exocytosis (cAMP-GEFII), (c) endocytosis (PRA1 and GIT1), (d) protein turnover (Siah1), (e) membrane trafficking (Epc2), (f) calcium signaling (L-type [Ca.sup.2+] channel), (g) scaffolding (Bassoon, RIM, Munc13, and ELKS), and (h) SV priming (RIM, Munc13) (Figure 4(a)).
These genes can be grouped into several categories based on their protein function and their involvement in (i) protein homeostasis, such as optineurin [8], valosin-containing protein [9], ubiquilin 2 [10], and TBK1 [11]; (ii) RNA metabolism and function such as TAR DNA-binding protein 43 (TDP-43), fused in sarcoma/translocated in liposarcoma (FUS/TLS) [12], C9orf72 [13,14], matrin 3 [15], and angiogenin [16]); (iii) cytoskeletal dynamics of motor axons such as dynactin subunit 1 [17], profilin 1 [18], and tubulin alpha-4 A chain [19]; (iv) mitochondrial function such as CHCHD10 [20]; and (v) regulation of inflammation such as TBK1 [11].
Overexpression of a Profilin (GhPFN2) promotes the progression of developmental phases in cotton fibers.