proestrogen

proestrogen

 [pro-es´tro-jen]
a substance without estrogenic activity but which is metabolized in the body to active estrogen.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pro·es·tro·gen

(prō-es'trō-jen),
A substance that acts as an estrogen only after it has been metabolized in the body to an active compound.
Farlex Partner Medical Dictionary © Farlex 2012

pro·es·tro·gen

(prō-es'trŏ-jen)
A substance that acts as an estrogen only after it has been metabolized in the body to an active compound.
Synonym(s): pro-oestrogen.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

pro·es·tro·gen

(prō-es'trŏ-jen)
Substance that acts as an estrogen only after it has been metabolized in the body to an active compound.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
In addition, it was recently discovered that isoxanthohumol, another hop-derived prenylflavonoid that is usually present in much larger quantities, can act as proestrogen as it can be metabolized into 8-PN by the intestinal microbiota (Possemiers et al., 2006, 2005).
Both the relatively small sample scale and factors affecting the bioavailability may have contributed to the absence of a clear dose-response relationship, as large interindividual differences in metabolic activation of the proestrogen IX to 8-PN exist in a typical menopausal population (Bolca et al., 2007).
The key compounds to be monitored in the chemical standardization process are: XH (major compound/ chemopreventive), IX (weak estrogen/stability marker), DMX (proestrogen), and 8-prenylnaringenin (estrogen/stability marker).
Further, methoxychlor is a proestrogen that requires demethylation by liver microsomal mixed function oxidase in animals before eliciting estrogenic activity (Kupfer and Bulger 1987; Stresser and Kupfer 1998).
Proestrogens, such as mestranol, are known to require metabolic transformation to exert estrogenic effects (Schmider et al.
Further, methoxychlor, trans-stilbene, benzophenone, and benzo[a]pyrene are proestrogens that require metabolic activation by liver microsomal mixed-function oxidase in animals (Charles et al.
Metabolic activation of the proestrogens trans-stilbene and trans-stilbene oxide by rat liver microsomes.
Also, it is unclear to what degree proestrogens may, or may not, be activated to their estrogenic form in cultured cells.