proenzyme

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proenzyme

 [pro-en´zīm]
zymogen; an inactive precursor of an enzyme.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pro·en·zyme

(prō-en'zīm),
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active; for example, pepsinogen, trypsinogen, profibrolysin.
Synonym(s): zymogen
Farlex Partner Medical Dictionary © Farlex 2012

proenzyme

(prō-ĕn′zīm′)
n.
The inactive or nearly inactive precursor of an enzyme, converted into an active enzyme by proteolysis. Also called zymogen.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

pro·en·zyme

(prō-en'zīm)
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active, e.g., pepsinogen, trypsinogen, profibrinolysin.
Synonym(s): zymogen.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

proenzyme

A protein that can give rise to an enzyme.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The company's lead product candidate, PRP, is a formulation of two proenzymes, designed to act synergistically against solid tumors which are malignant.
Endogenous NO can inhibit PCD by direct S-nitrosation of either active caspases or their proenzymes (Kim et al., 1997; Liu and Stamler, 1999; Kolb, 2000; Boyd and Cadenas, 2002; Wang et al., 2002; Brune, 2003).
Within the phenoloxidase system (factor 2), four proenzymes (A1, A2, A3, and PHOX) are involved (Seybold et al.
ENPNewswire-August 14, 2019--CORRECTING and REPLACING Propanc Biopharma Publishes Key Data in Peer Reviewed Journal Confirming Anti-Cancer Stem Cell Effects of Proenzymes
PRP is a mixture of two proenzymes, trypsinogen and chymotrypsinogen, administered by intravenous injection.
The objective of the POP1 joint drug discovery programme is to identify and develop suitable backup compounds to Propanc's lead product candidate PRP, a solution for intravenous administration of a combination of two pancreatic proenzymes trypsinogen and chymotrypsinogen.
They exist in the cytosol and the cellular membrane as inactive proenzymes but they are activated by an intracellular increase in [Ca.sup.2+] concentration.
Many of the MMPs are specifically regulated at the level of gene expression, but their production as inactive proenzymes is another important level of functional regulation [6].
The acinar cells of the pancreas produce and transport a variety of chemical compounds called proenzymes which are stored in zymogen granules that exit the body via the digestive system where the proenzymes are converted into active enzymes and assist in the digestion of fats, proteins, and carbohydrates.
Moreover, the study of MMP activity by immunohistochemical staining or mRNA analysis does not necessarily mean that matrix degradation will occur, since strict control of MMP activity is preserved when MMPs are released as inactive proenzymes or by the presence of inhibitors (26).
Therefore, NO can play a role in IL-1[beta]-induced suppression of glycosaminoglycan and collagen synthesis, expression of MMPs, and activation of proenzymes [9].