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(prō'en-kef'ă-lin), [MIM*131330]
A precursor protein that contains several enkephalin sequences. Compare: propiocortin.
References in periodicals archive ?
The possible existence of two proenkephalin genes within sturgeon, however, lends the first tangible support to this hypothesis.
Experiments have shown polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes are related to heroin abuse and gene expression in the human striatum.
Opioid neuropeptide genotypes in relation to heroin abuse: Dopamine tone contributes to reversed mesolimbic proenkephalin expression.
The main groups of opioid peptides, enkephalins, dynorphins and beta-endorphin, are derived from proenkephalin, prodynorphin and proopiomelanocortin, respectively (20).
Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus.
Similarly, chronic cannabinoid treatment increases gene expression of prodynorphin (which is a precursor to dynorphin A and dynorphin B, both additional opioids) and the opioid proenkephalin in brain regions mediating pain relief and drug dependence (Corchero et al.
Delta-9-tetrahydrocannabinol increases prodynorphin and proenkephalin gene expression in the spinal cord of the rat.