prodrug


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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).
Farlex Partner Medical Dictionary © Farlex 2012

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
The time-lapsed [sup.1]H x NMR spectra in [D.sub.2]O (Figure S8) suggest lability of the chloro and also possibly imidazole ligands over time, demonstrating favorable characteristics for desired in vivo prodrug applications.
First, Bcl-2 overexpression would only transiently occur during the short (<1 week) window in which NSC survival is critical for maximum prodrug conversion and tumor tropism.
The rate constants ([K.sub.obs]) and the corresponding half-lives ([t.sub.1/2]) for the prodrug were calculated (Tables 7 and 8).
Of the tested prodrugs, the sulfenamide with a cyclohexyl tail (prodrug 1) appeared to be the most active inhibitor for both AChE and BuChE ([IC.sub.50] = 890 and 28 nmol/mL, resp.) thus demonstrating a dual-binding property that favours the inhibition of BuChE.
(OTCQB: NSPX), a clinical-stage biotechnology company that has a patented technology platform utilizing thapsigargin for its prodrug delivery system, mipsagargin.
Recently, macromolecular prodrug design (MPDD) and applications based on etherified renewable polysaccharides especially cellulose, e.g., hydroxypropylcellulose (HPC) [2], hydroxypropylmethylcellulose (HPMC) [5, 9], hydroxyethylcellulose [13], etc., have emerged as thrust area of research.
Many therapeutic drugs have undesirable properties that may become pharmacological, pharmaceutical, or pharmacokinetic barriers in clinical drug application; one of the most promising strategies for precise and efficient drug delivery and enhancement of a drug therapeutic effect is the prodrug design approach which is becoming more elaborate in the development of efficient and selective drug delivery systems [29].
French researchers have introduced a new approach in Angewandte Chemie: the enzyme B-galactosidase releases the active drug from an inactive precursor, known as a prodrug, which only can be taken up by tumor cells.
The enzyme will then activate the prodrug, killing only the cancer cells.
Cascade Prodrug Inc., a Eugene drug development company using technology licensed from the University of Oregon, won the $200,000 investment prize Thursday in the fourth annual Willamette Angel Conference.
Fostoin is a water-soluble prodrug of phenytoin injection, a drug that has long been used both in Japan and overseas as a treatment for status epilepticus and other such conditions.
In a new approach, the group from the University's Departments of Chemistry and Biochemistry and Biological Sciences and the Friemann Life Sciences Centre, used a prodrug strategy to address this issue.