prodrug


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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
References in periodicals archive ?
The time-lapsed [sup.1]H x NMR spectra in [D.sub.2]O (Figure S8) suggest lability of the chloro and also possibly imidazole ligands over time, demonstrating favorable characteristics for desired in vivo prodrug applications.
First, Bcl-2 overexpression would only transiently occur during the short (<1 week) window in which NSC survival is critical for maximum prodrug conversion and tumor tropism.
The rate constants ([K.sub.obs]) and the corresponding half-lives ([t.sub.1/2]) for the prodrug were calculated (Tables 7 and 8).
Of the tested prodrugs, the sulfenamide with a cyclohexyl tail (prodrug 1) appeared to be the most active inhibitor for both AChE and BuChE ([IC.sub.50] = 890 and 28 nmol/mL, resp.) thus demonstrating a dual-binding property that favours the inhibition of BuChE.
(OTCQB: NSPX), a clinical-stage biotechnology company that has a patented technology platform utilizing thapsigargin for its prodrug delivery system, mipsagargin.
Recently, macromolecular prodrug design (MPDD) and applications based on etherified renewable polysaccharides especially cellulose, e.g., hydroxypropylcellulose (HPC) [2], hydroxypropylmethylcellulose (HPMC) [5, 9], hydroxyethylcellulose [13], etc., have emerged as thrust area of research.
Many therapeutic drugs have undesirable properties that may become pharmacological, pharmaceutical, or pharmacokinetic barriers in clinical drug application; one of the most promising strategies for precise and efficient drug delivery and enhancement of a drug therapeutic effect is the prodrug design approach which is becoming more elaborate in the development of efficient and selective drug delivery systems [29].
French researchers have introduced a new approach in Angewandte Chemie: the enzyme B-galactosidase releases the active drug from an inactive precursor, known as a prodrug, which only can be taken up by tumor cells.
The enzyme will then activate the prodrug, killing only the cancer cells.
Cascade Prodrug Inc., a Eugene drug development company using technology licensed from the University of Oregon, won the $200,000 investment prize Thursday in the fourth annual Willamette Angel Conference.
Fostoin is a water-soluble prodrug of phenytoin injection, a drug that has long been used both in Japan and overseas as a treatment for status epilepticus and other such conditions.
In a new approach, the group from the University's Departments of Chemistry and Biochemistry and Biological Sciences and the Friemann Life Sciences Centre, used a prodrug strategy to address this issue.