Rectal infection can result in proctocolitis
that can present with mucoid and/or hemorrhagic rectal discharge, anal pain, constipation, fever, and tenesmus, and signs of granulomas and/or ulcerations on anoscopy (1,2).
Cow's milk protein allergy may present with bloody stools and proctocolitis
Occasionally, non IgE-mediated food allergy can be responsible for more serious conditions such as eosinophilic eosophagitis, proctocolitis
and food protein induced enterocolitis syndromes (FPIES).
These delayed reactions commonly involve the gastrointestinal tract (e.g., food protein-induced enteropathy, proctocolitis
, or eosinophilic oesophagitis) or skin (eczema).
Non-IgE-mediated conditions include combined IgE- and cell-mediated conditions, such as atopic dermatitis and eosinophilic oesophagitis, and pure T-cell-mediated conditions, such as food protein-induced enterocolitis syndrome, allergic proctocolitis
and enteropathy syndromes.
ABM clinical protocol #24: Allergic proctocolitis
in the exclusively breastfed infant.
Mayberry, "Epidemiological study of ulcerative proctocolitis
in Indian migrants and the indigenous population of Leicestershire," Gut, vol.
Since there are no effective laboratory methods for the diagnosis of non-IgE-mediated FA, suspected in patients with symptoms suggestive of proctocolitis
and enterocolitis, or in patients with diagnosis of eosinophilic esophagitis and atopic dermatitis moderate to severe, an elimination diet without a suspected allergenic protein and subsequent oral food challenge, which was open for children younger than 3 years and double-blind for children above 3 years, was used for diagnosis [5, 6].
Gastrointestinal system: Oral allergy syndrome, gastrointestinal anaphylaxis, food protein-induced proctocolitis
and enterocolitis, enteropathy syndrome.