proconvertin

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proconvertin

 [pro″kon-ver´tin]

fac·tor VII

in the clotting of blood, also known as: proconvertin (Owren), convertin, serum prothrombin conversion accelerator (de Vries, Alexander), stable factor (Stefanini), cofactor V (Owren), prothrombinogen (Quick), cothromboplastin (Mann and Hurn), serum accelerator (Jacox). Factor VII forms a complex with tissue thromboplastin and calcium to activate factor X. Factor VII is known to be involved in: the congenital deficiency of factor VII, with purpura and bleeding from mucous membranes, autosomal recessive inheritance; the acquired deficiency of factor VII in association with a deficiency of vitamin K, neonatal patients, and the administration of prothrombinopenic drugs; the acquired excess of factor VII in some patients with thromboembolism. It accelerates the conversion of prothrombin to thrombin, in the presence of tissue thromboplastin, calcium, and factor V.

proconvertin

/pro·con·ver·tin/ (-kon-ver´tin) coagulation factor VII.

proconvertin

factor VII

A coagulation factor that forms a complex with thromboplastin and calcium to activate factor X.

fac·tor VII

(fak'tŏr)
A plasma factor in blood coagulation, forms a complex with tissue thromboplastin and calcium to activate factor X; accelerates the conversion of prothrombin to thrombin, in the presence of tissue thromboplastin, calcium, and factor V.
Synonym(s): cothromboplastin, proconvertin, serum accelerator, serum prothrombin conversion accelerator.

fac·tor VII

(fak'tŏr)
In blood clotting, forms a complex with tissue thromboplastin and calcium to activate factor X.
Synonym(s): prothrombinogen.

proconvertin (prō´kənvur´tin),

n (autoprothrombin I, cofactor V, cothromboplastin, factor VII, precursor of serum prothrombin conversion accelerator pro-SPCA], stable factor), variously described as the inactive precursor of convertin. Recently proconvertin has been considered as a collective term for pro-SPCA and Stuart factor.

proconvertin

clotting factor VII.

proconvertin deficiency
occurs in Beagle dogs and also Alaskan malamutes, causing no apparent bleeding tendency but may be associated with a predisposition to demodectic mange.