Shilajit: a natural phytocomplex with potential procognitive
Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychoticlike and procognitive
effects in rodents.
The pharmacological model based on scopolamine, which temporarily blocks muscarinic cholinergic receptors in the brain, is widely regarded as a standard model for investigating cognitive deficits and may be useful in the search for improved procognitive
 Activation of the [alpha]7 receptors increases cholinergic neurotransmission and the release of glutamate (Glu) and dopamine (DA) exerts procognitive
effects in rats.
effects of leptin in the brain and their clinical implications.
As no preventative treatments for dementia currently exist, the potential procognitive
effects of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation have been investigated by a multitude of clinical trials [7, 8], including a recent trial in CAD patients .
Munari, "Antidepressant, mood stabilizing and procognitive
effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression," International Journal of Neuropsychopharmacology, vol.
This may be of potential interest because of preclinical findings of a possible procognitive
effect mediated by action at the serotonin 5-HT7 receptor [60, 61].
This clustering may be due to the presence of coumarins, which are known to have various effects on the central nervous system in vitro and in vivo, including anticonvulsant, anxiolytic, antidepressive, neuroprotective and procognitive
activities (Skalicka-Wozniak et al., 2016).
Heaps of data are pouring into neuroscience literature, all converging to demonstrate rather procognitive
effects of lithium.
While not a measure of intellectual performance, a procognitive
personality indicates an interest in abstract ideas, a drive to understand phenomena on a deep level and a willingness to expend considerable mental effort in solving problems (Ardelt, 2003).
Secondary receptor properties shared by some of these drugs may be sedating and may interfere with the drugs' procognitive
actions Muscarinic cholinergic receptor antagonism seen with olanzapine and quetiapine may interfere with procholinergic actions on acetylcholine release related to improved cognition.