procognitive

procognitive

(prō-kog-nĭ-tiv),
Denoting a drug which reduces delirium or disorientation.
References in periodicals archive ?
The procognitive effects of leptin in the brain and their clinical implications.
7] Activation of the [alpha]7 receptors increases cholinergic neurotransmission and the release of glutamate (Glu) and dopamine (DA) exerts procognitive effects in rats.
This clustering may be due to the presence of coumarins, which are known to have various effects on the central nervous system in vitro and in vivo, including anticonvulsant, anxiolytic, antidepressive, neuroprotective and procognitive activities (Skalicka-Wozniak et al.
Heaps of data are pouring into neuroscience literature, all converging to demonstrate rather procognitive effects of lithium.
While not a measure of intellectual performance, a procognitive personality indicates an interest in abstract ideas, a drive to understand phenomena on a deep level and a willingness to expend considerable mental effort in solving problems (Ardelt, 2003).
Secondary receptor properties shared by some of these drugs may be sedating and may interfere with the drugs' procognitive actions Muscarinic cholinergic receptor antagonism seen with olanzapine and quetiapine may interfere with procholinergic actions on acetylcholine release related to improved cognition.
and Europe and was designed to determine the safety and efficacy of EVP-6124 in producing procognitive effects and improving the clinical condition of Alzheimer's disease patients.
EHT 0202 is ExonHit's lead candidate in Alzheimer's disease and potentially first in a new class of disease modifying therapies which stimulate the -secretase pathway, thus enhancing the production of the procognitive and neuroprotective sAPP fragment of APP (Amyloid Precursor Protein).
EHT 0202 has a novel mechanism of action when compared to existing Alzheimer's disease therapeutics: it stimulates the -secretase pathway, thus enhancing the production of the procognitive and neuroprotective sAPP fragment of APP (Amyloid Precursor Protein).
There is a high unmet need for new Alzheimer treatments with procognitive and neuroprotective properties.
In light of the neuroprotective and procognitive effects demonstrated by EHT 0202 in preclinical studies, we believe that our drug candidate has the potential to modify the course of Alzheimer's disease and might open a new era in the treatment of this devastating disease," commented Dr.
Profile of SEN-12333 published - neuroprotection and procognitive activity demonstrated in Alzheimer's disease models - SEN-12333 is unlikely to be developed clinically however we believe that its profile is encouraging.