Junke et al., "Once versus twice daily injection of enoxaparin for thromboprophylaxis in bariatric surgery: effects on antifactor Xa activity and procoagulant
Gerlach et al., "Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant
activity, and promotes monocyte migration," Journal of Experimental Medicine, vol.
Platelets provide a procoagulant
surface for amplification of cancer-related coagulation.
actions of these components are proved experimentally .
It is currently widely accepted that a protein S deficiency is a significant contributor to the procoagulant
nature of HIV disease.
(3) In vertebrates, clotting and inflammation have diverged into the specialized functions of the platelets, phagocytic cells (neutrophils and macrophages), and several plasma protein systems (procoagulant
proteins, complement proteins, proteins of the kinin system).
Hence, there is a decrease in both procoagulant
and anticoagulant proteins.
Thrombin generation in TF-activated plasma requires the presence of procoagulant
phospholipid membranes for the assembly of thrombin-generating enzyme complexes (17).
The latter could be taken as an index of thrombin generation reflecting the overall balance of procoagulants
and anticoagulants of plasma ex vivo.
activity has been shown to be associated with stage of the disease.
The first, represented by the procoagulant
factors, is triggered by tissue factor (TF), (3) a cellular receptor in damaged tissues that forms a complex with activated factor VII (FVIIa) at the site of injury (Fig.
After liver resection, a degree of hepatic insufficiency can result in reduced levels of procoagulant
and anticoagulant factors normally synthesised in the liver.