procoagulant factor


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procoagulant factor

A lymphokine that can assume the role of factor VIII (antihemophilic factor) in coagulation cascade.
See also: factor
References in periodicals archive ?
Monocyte participates in the prothrombotic condition directly via the secretion of procoagulant factors and indirectly by promoting inflammation process.
VTE is a multicausal disease with many interactions between different acquired (immobilization, surgery, trauma, cancer, autoimmune disorders, pregnancy, oral contraceptive use, long distance airplane flight, etc.) and inherited prothrombotic factors (FV Leiden and FII 20210A mutations, deficiencies of protein C, S and antithrombin, and elevations of procoagulant factors) (8).
One important way in which endothelial cells control the clotting system is by regulating the expression of binding sites for anticoagulant and procoagulant factors in the glycocalyx on the endothelial cell surface.
In other words, PT and APTT results can tell us whether there is a coagulation deficiency of one or more procoagulant factors, but not whether this deficiency is counterbalanced by a concomitant deficiency of the anticoagulant factors.
Evidence indicates that the fatty and inflamed liver expresses several pro-inflammatory and procoagulant factors, as well as genes involved in accelerated atherogenesis, explained lead investigator Raluca Pais, MD, PhD, of the Pierre and Marie Curie University, INSERM, and the CDR Saint Antoine, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.
(44) Use of PCCs in a broader population of trauma patients has not been evaluated in randomized controlled trials and may excessively increase thromboembolic risks due to the long half-lives of procoagulant factors in these products.
[7] The tumors, through the production of procoagulant factors, and the host, through its inflammatory response, participate in the process.