CASP3

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CASP3

A gene on chromosome 4q34 that encodes a so-called effector caspase belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis, as well as various stages of embryological development. CASP3 is highly expressed in the lung, spleen, heart, liver and kidney.
References in periodicals archive ?
Testicular apoptotic signaling was further evaluated by determining (a) the ratio of Bax protein level to Bcl2 protein level, along with the protein levels of (b) procaspase3 and (c) c-caspase3.
Antibodies against cleaved poly (ADP-ribose) polymerase (PARP), pro-PARP, cleaved caspase3, procaspase3, phosphorylated c-Jun N-terminal kinase (pJNK), and phosphorylated-p38 were obtained from Cell Signaling (Boston, MA).