Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specifc lung procarcinogen
4-(methylnitrosamino)1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13humanized mouse model.
The present review is devoted to studies on cytochrome P450 family 1 (CYP1), an important family of enzymes responsible for drug metabolism and procarcinogen
activation, with the use of molecular docking and molecular dynamics simulations.
This change might weaken the capability on procarcinogen
metabolism of body and therefore increased susceptibility to cancer [16, 17].
Nagarajan, "Morin and Esculetin supplementation modulates c-myc induced energy metabolism and attenuates neoplastic changes in rats challenged with the procarcinogen
1,2-dimethylhydrazine," European Journal of Pharmacology, vol.
The CYP1A1 gene regulates the P450-1A1 enzyme that converts polycyclic aromatic hydrocarbons, such as the procarcinogen
benzo[a]pyrene, into benzo[a]pyrene diol epoxide carcinogens.
There are some metabolic pathways which lead to inactivation of procarcinogen
or its derivatives.
Researchers from the University of California, San Diego School of Medicine, say the chemical disrupted liver integrity and compromised liver function in mice models that were given a procarcinogen
to promote liver cancer.
Beside acting as scavenger for reactive oxygen and nitrogen species, green tea also enhances the level of some detoxifying enzymes (Sohn et al., 1994).The procarcinogen
activating enzyme cytochrome P450 is also suppressed (Muto et al., 2001).Green tea and EGCG also bind to metal ions and further reduce the generation of reactive free radicals (Hider et al., 2001).
It may also play an indirect role in the conversion of procarcinogen
to the ultimate carcinogens (9, 10, 11).
It also causes recurrent kidney stones; is a probable procarcinogen
for gastric cancer; and has a pathophysiologic basis for causing osteoporosis, obesity, cardiovascular disease independent of blood pressure, and increased severity and frequency of asthma attacks (1).
That's right, and (very unfortunately for the men involved) my observation has been that many men who take finasteride to suppress procarcinogenic DHT end up suppressing their own anticarcinogenic 3 [beta] -Adiol even more, thus shifting the procarcinogen
(DHT) to anticarcinogen (3 [beta] -Adiol) ratio toward a greater risk of cancer.
The studies clearly indicated that the administration of zinc in the presence of procarcinogen
1, 2 dimehtylhydrazine (DMH) brings about decrease in tumour incidence and tumour burden as well as profound alterations in the antioxidant status with restoration of normal colonic histoarchitecture.